TY - JOUR
T1 - Risk Factors Associated with Cystoid Macular Edema among Patients Undergoing Primary Repair of Rhegmatogenous Retinal Detachment
AU - Shah, Yesha S.
AU - Abidi, Muhammad
AU - Ahmed, Ishrat
AU - Arsiwala-Scheppach, Lubaina T.
AU - Ong, Sally
AU - Wu, David
AU - Handa, James T.
N1 - Publisher Copyright:
© 2023 American Academy of Ophthalmology
PY - 2024/5
Y1 - 2024/5
N2 - Purpose: To investigate predictors of the development and resolution of cystoid macular edema (CME) after rhegmatogenous retinal detachment (RRD) repair. Design: Retrospective cross sectional study. Subjects: Patients who underwent primary repair of uncomplicated RRD. Methods: Demographics, ophthalmic history, visual acuity, RRD features, time to development/resolution of CME, OCT characteristics of CME/epiretinal membrane (ERM), type of surgery, and treatments were collected. Logistic regressions were used to identify predictors of CME development and resolution. Main Outcome Measures: Predictors of CME development and resolution. Results: A total of 708 eyes were included, of which 55 (7.8%) developed CME. Factors associated with an increased risk of CME development included total number of retinal detachment surgeries (odds ratio [OR] 1.66 [1.24–2.23], P < 0.001), prior intraocular surgery (OR 4.43 [1.19–16.51], P = 0.03), and presence of ERM after surgery (OR 4.49 [2.30–8.74], P < 0.001). Patients undergoing pars plana vitrectomy (PPV) were more likely to develop CME compared with patients undergoing scleral buckling (SB; OR 3.09 [1.18–8.10], P = 0.02). A longer average time to CME detection was associated with lower CME resolution (OR 0.94 [0.89–0.998], P = 0.04). In patients who developed an ERM postsurgically, those who developed CME after ERM had a lower rate of resolution compared with those who developed CME before ERM (P = 0.03). Conclusions: Cystoid macular edema may be more likely to develop in patients undergoing PPV than SB, those who underwent more surgeries for RRD repair, those who had prior intraocular surgery, or those who developed an ERM after RRD repair. Resolution of CME may be affected by the time to detection of CME and ERM development. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
AB - Purpose: To investigate predictors of the development and resolution of cystoid macular edema (CME) after rhegmatogenous retinal detachment (RRD) repair. Design: Retrospective cross sectional study. Subjects: Patients who underwent primary repair of uncomplicated RRD. Methods: Demographics, ophthalmic history, visual acuity, RRD features, time to development/resolution of CME, OCT characteristics of CME/epiretinal membrane (ERM), type of surgery, and treatments were collected. Logistic regressions were used to identify predictors of CME development and resolution. Main Outcome Measures: Predictors of CME development and resolution. Results: A total of 708 eyes were included, of which 55 (7.8%) developed CME. Factors associated with an increased risk of CME development included total number of retinal detachment surgeries (odds ratio [OR] 1.66 [1.24–2.23], P < 0.001), prior intraocular surgery (OR 4.43 [1.19–16.51], P = 0.03), and presence of ERM after surgery (OR 4.49 [2.30–8.74], P < 0.001). Patients undergoing pars plana vitrectomy (PPV) were more likely to develop CME compared with patients undergoing scleral buckling (SB; OR 3.09 [1.18–8.10], P = 0.02). A longer average time to CME detection was associated with lower CME resolution (OR 0.94 [0.89–0.998], P = 0.04). In patients who developed an ERM postsurgically, those who developed CME after ERM had a lower rate of resolution compared with those who developed CME before ERM (P = 0.03). Conclusions: Cystoid macular edema may be more likely to develop in patients undergoing PPV than SB, those who underwent more surgeries for RRD repair, those who had prior intraocular surgery, or those who developed an ERM after RRD repair. Resolution of CME may be affected by the time to detection of CME and ERM development. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
KW - Cystoid macular edema
KW - Epiretinal membrane
KW - Rhegmatogenous retinal detachment
KW - Risk factors
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U2 - 10.1016/j.oret.2023.11.013
DO - 10.1016/j.oret.2023.11.013
M3 - Article
C2 - 38036083
AN - SCOPUS:85181070761
SN - 2468-7219
VL - 8
SP - 456
EP - 464
JO - Ophthalmology Retina
JF - Ophthalmology Retina
IS - 5
ER -