Risk Assessment of Human Papillomavirus-Positive Cytology-Negative Cervical Cancer Screening in Black and White Women

Daniel L. Miller, Ashleigh Graham, Katelynn E. Davis, Harsimar Kaur, Marissa White, Zahra Maleki, Erika F. Rodriguez

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: As we move toward human papillomavirus (HPV) only as the preferred cervical cancer screening method, we performed a retrospective analysis of Black and White women with negative cytology (Papanicolaou negative [PAPneg]) and positive high-risk HPV (hrHPV) (HPVpos) results and determined follow-up. Methods: We searched our pathology data system for patients with PAPneg/HPVpos results (2017-2019). Follow-up data were reviewed (39 months), and a comparison among race was performed. Results: In total, 1,728 patients were identified (Black, 53%; White, 47%). Twenty-nine percent of the patients had no follow-up with no difference among the races. HPV 16 was more common among Whites (P < .01), while non-16/18 hrHPV was more common among Black patients (P = .01). A total of 30 (3.3%) Black and 26 (3.2%) White patients were diagnosed with cervical intraepithelial neoplasia grade 2/3 (CIN 2/3). More White women were diagnosed on biopsy alone (negative endocervical curettage) compared with Black women (20 vs 9, P < .01). Meanwhile, there were 21 Black and 6 White women with CIN 2/3 on endocervical curettage (P = .01). Conclusions: Follow-up of women with PAPneg/HPVpos remains a challenge. There was no disparity in follow-up when cohorts were compared. However, Black women had higher numbers of high-grade intraepithelial lesions on endocervical curettage.

Original languageEnglish (US)
Pages (from-to)399-405
Number of pages7
JournalAmerican journal of clinical pathology
Volume157
Issue number3
DOIs
StatePublished - Mar 1 2022

Keywords

  • Cervical intraepithelial neoplasia
  • Human papillomavirus type 16
  • Human papillomavirus type 18
  • Papanicolaou test
  • Papillomavirus infections
  • Uterine cervical neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint

Dive into the research topics of 'Risk Assessment of Human Papillomavirus-Positive Cytology-Negative Cervical Cancer Screening in Black and White Women'. Together they form a unique fingerprint.

Cite this