Right Ventricular Dysfunction in Chronic Lung Disease

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Right ventricular (RV) dysfunction arises in chronic lung disease when chronic hypoxemia and disruption of pulmonary vascular beds increase ventricular afterload. RV dysfunction is defined by hypertrophy with preserved myocardial contractility and cardiac output. RV hypertrophy seems to be a common complication of chronic and advanced lung disease. RV failure is rare, except during acute exacerbations of chronic lung disease or when multiple comorbidities are present. Treatment is targeted at correcting hypoxia and improving pulmonary gas exchange and mechanics. There are no data supporting the use of pulmonary hypertension-specific therapies for patients with RV dysfunction secondary to chronic lung disease.

Original languageEnglish (US)
Pages (from-to)243-256
Number of pages14
JournalCardiology clinics
Issue number2
StatePublished - May 2012


  • Chronic lung disease
  • Cor pulmonale
  • Pulmonary hypertension
  • Right ventricle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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