TY - JOUR
T1 - Rice Consumption and Subclinical Lung Disease in US Adults
T2 - Observational Evidence from the Multi-Ethnic Study of Atherosclerosis
AU - Sanchez, Tiffany R.
AU - Oelsner, Elizabeth C.
AU - Lederer, David J.
AU - Lo Cascio, Christian M.
AU - Jones, Miranda R.
AU - Grau-Perez, Maria
AU - Francesconi, Kevin A.
AU - Goessler, Walter
AU - Perzanowski, Matthew S.
AU - Graham Barr, R.
AU - Navas Acien, Ana
N1 - Funding Information:
This research was supported by grants R01HL103676 and K24HL131937 and by contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, and N01-HC-95169 from the National Heart, Lung, and Blood Institute; by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the National Center for Advancing Translational Sciences; by grants R01ES025216, R01ES021367, P42ES10349, and P30ES009089 from the National Institute of Environmental Health Sciences; and a grant from the Pulmonary Fibrosis Foundation.
Publisher Copyright:
© 2019 The Author(s).
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Rice accumulates arsenic, an established lung toxicant. Little is known about the association of rice consumption with arsenic-related health effects, particularly interstitial lung disease. Between 2000 and 2002, 6,814 white, black, Hispanic, and Chinese adults from 6 US cities were enrolled in the Multi-Ethnic Study of Atherosclerosis. We included 2,250 participants who had spirometry data, 2,557 with full-lung computed tomography (CT) scans, and 5,710 with cardiac CT scans. Rice consumption and 310 participants with urinary arsenic were assessed at baseline. Spirometry and full-lung CT-derived measures of total lung capacity and high attenuation area (HAA), and interstitial lung abnormalities were measured at examination 5. Cardiac CT-derived HAA was measured at 1-3 visits. Twelve percent of participants reported eating at least 1 serving of rice daily. Comparing data between that group with those who ate less than 1 serving weekly, the mean difference for forced vital capacity was-102 (95% confidence interval (CI):-198,-7) mL, and for forced expiratory volume in 1 second was-90 (95% CI:-170,-11) mL after adjustment for demographics, anthropometrics, dietary factors, and smoking. The cross-sectional adjusted percent difference for total lung capacity was-1.33% (95% CI:-4.29, 1.72) and for cardiac-based HAA was 3.66% (95% CI: 1.22, 6.15). Sensitivity analyses for urinary arsenic were consistent with rice findings. Daily rice consumption was associated with reduced lung function and greater cardiac-based HAA.
AB - Rice accumulates arsenic, an established lung toxicant. Little is known about the association of rice consumption with arsenic-related health effects, particularly interstitial lung disease. Between 2000 and 2002, 6,814 white, black, Hispanic, and Chinese adults from 6 US cities were enrolled in the Multi-Ethnic Study of Atherosclerosis. We included 2,250 participants who had spirometry data, 2,557 with full-lung computed tomography (CT) scans, and 5,710 with cardiac CT scans. Rice consumption and 310 participants with urinary arsenic were assessed at baseline. Spirometry and full-lung CT-derived measures of total lung capacity and high attenuation area (HAA), and interstitial lung abnormalities were measured at examination 5. Cardiac CT-derived HAA was measured at 1-3 visits. Twelve percent of participants reported eating at least 1 serving of rice daily. Comparing data between that group with those who ate less than 1 serving weekly, the mean difference for forced vital capacity was-102 (95% confidence interval (CI):-198,-7) mL, and for forced expiratory volume in 1 second was-90 (95% CI:-170,-11) mL after adjustment for demographics, anthropometrics, dietary factors, and smoking. The cross-sectional adjusted percent difference for total lung capacity was-1.33% (95% CI:-4.29, 1.72) and for cardiac-based HAA was 3.66% (95% CI: 1.22, 6.15). Sensitivity analyses for urinary arsenic were consistent with rice findings. Daily rice consumption was associated with reduced lung function and greater cardiac-based HAA.
KW - Oryza
KW - arsenic
KW - interstitial lung disease
KW - spirometry
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U2 - 10.1093/aje/kwz137
DO - 10.1093/aje/kwz137
M3 - Article
C2 - 31145426
AN - SCOPUS:85072058322
SN - 0002-9262
VL - 188
SP - 1655
EP - 1665
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 9
ER -