Ribozyme catalysis: Not different, just worse

Jennifer A. Doudna, Jon R. Lorsch

Research output: Contribution to journalReview articlepeer-review

121 Scopus citations


Evolution has resoundingly favored protein enzymes over RNA-based catalysts, yet ribozymes occupy important niches in modern cell biology that include the starring role in catalysis of protein synthesis on the ribosome. Recent results from structural and biochemical studies show that natural ribozymes use an impressive range of catalytic mechanisms, beyond metalloenzyme chemistry and analogous to more chemically diverse protein enzymes. These findings make it increasingly possible to compare details of RNA- and protein-based catalysis.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalNature Structural and Molecular Biology
Issue number5
StatePublished - May 1 2005

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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