Ribosome states signal RNA quality control

Karole N. D'Orazio; Rachel Green

doi:10.1016/j.molcel.2021.02.022

Ribosome states signal RNA quality control

Karole N. D'Orazio, Rachel Green

Howard Hughes Medical Institution

Research output: Contribution to journal › Review article › peer-review

Abstract

D'Orazio and Green analyze ribosome-dependent pathways involved in RNA quality control. They discuss how the many states of a ribosome during translation of a problematic mRNA signal a number of mRNA quality control pathways, with overlapping and compensatory mechanisms that ensure mRNA and protein degradation.

Original language	English (US)
Pages (from-to)	1372-1383
Number of pages	12
Journal	Molecular cell
Volume	81
Issue number	7
DOIs	https://doi.org/10.1016/j.molcel.2021.02.022
State	Published - Apr 1 2021

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2021.02.022

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title = "Ribosome states signal RNA quality control",

abstract = "D'Orazio and Green analyze ribosome-dependent pathways involved in RNA quality control. They discuss how the many states of a ribosome during translation of a problematic mRNA signal a number of mRNA quality control pathways, with overlapping and compensatory mechanisms that ensure mRNA and protein degradation.",

author = "D'Orazio, {Karole N.} and Rachel Green",

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year = "2021",

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doi = "10.1016/j.molcel.2021.02.022",

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AU - Green, Rachel

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N2 - D'Orazio and Green analyze ribosome-dependent pathways involved in RNA quality control. They discuss how the many states of a ribosome during translation of a problematic mRNA signal a number of mRNA quality control pathways, with overlapping and compensatory mechanisms that ensure mRNA and protein degradation.

AB - D'Orazio and Green analyze ribosome-dependent pathways involved in RNA quality control. They discuss how the many states of a ribosome during translation of a problematic mRNA signal a number of mRNA quality control pathways, with overlapping and compensatory mechanisms that ensure mRNA and protein degradation.

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DO - 10.1016/j.molcel.2021.02.022

M3 - Review article

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VL - 81

SP - 1372

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JO - Molecular cell

JF - Molecular cell

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Ribosome states signal RNA quality control

Abstract

ASJC Scopus subject areas

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