TY - JOUR
T1 - Rhythmic transcription
T2 - The molecular basis of circadian melatonin synthesis
AU - Foulkes, Nicholas S.
AU - Borjigin, Jimo
AU - Snyder, Solomon H.
AU - Sassone-Corsi, Paolo
N1 - Funding Information:
We wish to thank D. Whitmore, E. Borrelli and Z. Wang for discussions. Our studies are funded by the US Public Health Service (S.H.S.) and grants from CNRS, INSERM, CHUR, Rhône-Poulenc Rorer (Bioavenir), Fondation pour la Recherche Médicale and Association pour Recherche sur le Cancer (P.S.C.).
PY - 1997/10/1
Y1 - 1997/10/1
N2 - Adaptation to a changing environment is an essential feature of physiological regulation. The day-night rhythm is translated into hormonal oscillations governing the metabolism of all living organisms. In mammals the pineal gland is responsible for the synthesis of the hormone melatonin in response to signals originating from the endogenous clock located in the hypothalamic suprachiasmatic nucleus (SCN). The molecular mechanisms involved in rhythmic synthesis of melatonin involve the cAMP response element modulator (crem) gene, which encodes transcription factors responsive to activation of the cAMP signalling pathway. The CREM product, inducible cAMP early repressor (ICER), is rhythmically expressed and participates in a transcriptional autoregulatory loop that also controls the amplitude of oscillations of 5-HT N-acetyl transferase, the rate-limiting enzyme of melatonin synthesis. Thus, a transcription factor modulates the oscillatory levels of a hormone.
AB - Adaptation to a changing environment is an essential feature of physiological regulation. The day-night rhythm is translated into hormonal oscillations governing the metabolism of all living organisms. In mammals the pineal gland is responsible for the synthesis of the hormone melatonin in response to signals originating from the endogenous clock located in the hypothalamic suprachiasmatic nucleus (SCN). The molecular mechanisms involved in rhythmic synthesis of melatonin involve the cAMP response element modulator (crem) gene, which encodes transcription factors responsive to activation of the cAMP signalling pathway. The CREM product, inducible cAMP early repressor (ICER), is rhythmically expressed and participates in a transcriptional autoregulatory loop that also controls the amplitude of oscillations of 5-HT N-acetyl transferase, the rate-limiting enzyme of melatonin synthesis. Thus, a transcription factor modulates the oscillatory levels of a hormone.
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U2 - 10.1016/S0166-2236(97)01109-0
DO - 10.1016/S0166-2236(97)01109-0
M3 - Article
C2 - 9347618
AN - SCOPUS:0030879708
SN - 0378-5912
VL - 20
SP - 487
EP - 492
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 10
ER -