Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation

Wanchun Yang; Dejiang Pang; Mina Chen; Chongyangzi Du; Lanlan Jia; Luoling Wang; Yunling He; Wanxiang Jiang; Liping Luo; Zongyan Yu; Mengqian Mao; Qiuyun Yuan; Ping Tang; Xiaoqiang Xia; Yiyuan Cui; Bo Jing; Alexander Platero; Yanhui Liu; Yuquan Wei; Paul F. Worley; Bo Xiao

doi:10.1016/j.devcel.2021.02.022

Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation

Wanchun Yang, Dejiang Pang, Mina Chen, Chongyangzi Du, Lanlan Jia, Luoling Wang, Yunling He, Wanxiang Jiang, Liping Luo, Zongyan Yu, Mengqian Mao, Qiuyun Yuan, Ping Tang, Xiaoqiang Xia, Yiyuan Cui, Bo Jing, Alexander Platero, Yanhui Liu, Yuquan Wei, Paul F. WorleyBo Xiao

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Neuronal activity is coordinated with neuroenergetics. Yang et al. demonstrate that dynamic translocation of Rheb to mitochondrial matrix activates pyruvate dehydrogenase (PDH) independent of mTORC1 and mediates neuronal-activity-regulated mitochondrial metabolism. Their findings suggest a mechanism by which Rheb integrates PDH-dependent energy production and mTORC1-dependent energy consumption.

Original language	English (US)
Pages (from-to)	811-825.e6
Journal	Developmental Cell
Volume	56
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2021.02.022
State	Published - Mar 22 2021
Externally published	Yes

Keywords

Rheb
mTORC1
mitochondria
neuroenergetics
neuronal activity
pyruvate dehydrogenase

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2021.02.022

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Yang, W., Pang, D., Chen, M., Du, C., Jia, L., Wang, L., He, Y., Jiang, W., Luo, L., Yu, Z., Mao, M., Yuan, Q., Tang, P., Xia, X., Cui, Y., Jing, B., Platero, A., Liu, Y., Wei, Y., ... Xiao, B. (2021). Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation. Developmental Cell, 56(6), 811-825.e6. https://doi.org/10.1016/j.devcel.2021.02.022

Yang, W, Pang, D, Chen, M, Du, C, Jia, L, Wang, L, He, Y, Jiang, W, Luo, L, Yu, Z, Mao, M, Yuan, Q, Tang, P, Xia, X, Cui, Y, Jing, B, Platero, A, Liu, Y, Wei, Y, Worley, PF & Xiao, B 2021, 'Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation', Developmental Cell, vol. 56, no. 6, pp. 811-825.e6. https://doi.org/10.1016/j.devcel.2021.02.022

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abstract = "Neuronal activity is coordinated with neuroenergetics. Yang et al. demonstrate that dynamic translocation of Rheb to mitochondrial matrix activates pyruvate dehydrogenase (PDH) independent of mTORC1 and mediates neuronal-activity-regulated mitochondrial metabolism. Their findings suggest a mechanism by which Rheb integrates PDH-dependent energy production and mTORC1-dependent energy consumption.",

keywords = "Rheb, mTORC1, mitochondria, neuroenergetics, neuronal activity, pyruvate dehydrogenase",

author = "Wanchun Yang and Dejiang Pang and Mina Chen and Chongyangzi Du and Lanlan Jia and Luoling Wang and Yunling He and Wanxiang Jiang and Liping Luo and Zongyan Yu and Mengqian Mao and Qiuyun Yuan and Ping Tang and Xiaoqiang Xia and Yiyuan Cui and Bo Jing and Alexander Platero and Yanhui Liu and Yuquan Wei and Worley, {Paul F.} and Bo Xiao",

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year = "2021",

month = mar,

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doi = "10.1016/j.devcel.2021.02.022",

language = "English (US)",

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T1 - Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation

AU - Yang, Wanchun

AU - Pang, Dejiang

AU - Chen, Mina

AU - Du, Chongyangzi

AU - Jia, Lanlan

AU - Wang, Luoling

AU - He, Yunling

AU - Jiang, Wanxiang

AU - Luo, Liping

AU - Yu, Zongyan

AU - Mao, Mengqian

AU - Yuan, Qiuyun

AU - Tang, Ping

AU - Xia, Xiaoqiang

AU - Cui, Yiyuan

AU - Jing, Bo

AU - Platero, Alexander

AU - Liu, Yanhui

AU - Wei, Yuquan

AU - Worley, Paul F.

AU - Xiao, Bo

PY - 2021/3/22

Y1 - 2021/3/22

N2 - Neuronal activity is coordinated with neuroenergetics. Yang et al. demonstrate that dynamic translocation of Rheb to mitochondrial matrix activates pyruvate dehydrogenase (PDH) independent of mTORC1 and mediates neuronal-activity-regulated mitochondrial metabolism. Their findings suggest a mechanism by which Rheb integrates PDH-dependent energy production and mTORC1-dependent energy consumption.

AB - Neuronal activity is coordinated with neuroenergetics. Yang et al. demonstrate that dynamic translocation of Rheb to mitochondrial matrix activates pyruvate dehydrogenase (PDH) independent of mTORC1 and mediates neuronal-activity-regulated mitochondrial metabolism. Their findings suggest a mechanism by which Rheb integrates PDH-dependent energy production and mTORC1-dependent energy consumption.

KW - Rheb

KW - mTORC1

KW - mitochondria

KW - neuroenergetics

KW - neuronal activity

KW - pyruvate dehydrogenase

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DO - 10.1016/j.devcel.2021.02.022

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SN - 1534-5807

VL - 56

SP - 811-825.e6

JO - Developmental Cell

JF - Developmental Cell

IS - 6

ER -

Rheb mediates neuronal-activity-induced mitochondrial energetics through mTORC1-independent PDH activation

Abstract

Keywords

ASJC Scopus subject areas

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