Revisiting the Immunoglobulin Intramolecular Signaling Hypothesis

Anthony Bowen, Arturo Casadevall

Research output: Contribution to journalShort surveypeer-review

8 Scopus citations


A generation ago, the immunoglobulin intramolecular signaling, or allosteric, hypothesis was abandoned in favor of the associative hypothesis, which posited that Fc receptor crosslinking produced the increased affinity of antigen–antibody complexes. This essay argues that there is sufficient evidence to resuscitate the allosteric hypothesis, at least for some antibodies.

Original languageEnglish (US)
Pages (from-to)721-723
Number of pages3
JournalTrends in Immunology
Issue number11
StatePublished - Nov 1 2016


  • allosteric model
  • antibody
  • associative model
  • immunoglobulin
  • intramolecular signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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