Reversible dementia with idiopathic hypereosinophilic syndrome

P. W. Kaplan, L. Waterbury, C. Kawas, K. Bolla-Wilson, D. Durack

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


A 66-year-old woman with hypereosinophilic syndrome became rapidly demented. Evaluation revealed CSF eosinophilia, background slowing on EEG, and periventricular MRI abnormalities. Following steroid therapy, there was rapid resolution of the dementia and normalization of CSF and EEG. These findings support the concept of a direct neurotoxic effect on the human CNS produced either by eosinophils or possibly by eosinophil-derived neurotoxins.

Original languageEnglish (US)
Pages (from-to)1388-1391
Number of pages4
Issue number10
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Clinical Neurology


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