Reversible dementia with idiopathic hypereosinophilic syndrome

P. W. Kaplan; L. Waterbury; C. Kawas; K. Bolla-Wilson; D. Durack

doi:10.1212/wnl.39.10.1388

Reversible dementia with idiopathic hypereosinophilic syndrome

P. W. Kaplan, L. Waterbury, C. Kawas, K. Bolla-Wilson, D. Durack

School of Medicine

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39 Scopus citations

Abstract

A 66-year-old woman with hypereosinophilic syndrome became rapidly demented. Evaluation revealed CSF eosinophilia, background slowing on EEG, and periventricular MRI abnormalities. Following steroid therapy, there was rapid resolution of the dementia and normalization of CSF and EEG. These findings support the concept of a direct neurotoxic effect on the human CNS produced either by eosinophils or possibly by eosinophil-derived neurotoxins.

Original language	English (US)
Pages (from-to)	1388-1391
Number of pages	4
Journal	Neurology
Volume	39
Issue number	10
DOIs	https://doi.org/10.1212/wnl.39.10.1388
State	Published - Oct 1989

ASJC Scopus subject areas

Clinical Neurology

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abstract = "A 66-year-old woman with hypereosinophilic syndrome became rapidly demented. Evaluation revealed CSF eosinophilia, background slowing on EEG, and periventricular MRI abnormalities. Following steroid therapy, there was rapid resolution of the dementia and normalization of CSF and EEG. These findings support the concept of a direct neurotoxic effect on the human CNS produced either by eosinophils or possibly by eosinophil-derived neurotoxins.",

author = "Kaplan, {P. W.} and L. Waterbury and C. Kawas and K. Bolla-Wilson and D. Durack",

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AU - Kawas, C.

AU - Bolla-Wilson, K.

AU - Durack, D.

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Y1 - 1989/10

N2 - A 66-year-old woman with hypereosinophilic syndrome became rapidly demented. Evaluation revealed CSF eosinophilia, background slowing on EEG, and periventricular MRI abnormalities. Following steroid therapy, there was rapid resolution of the dementia and normalization of CSF and EEG. These findings support the concept of a direct neurotoxic effect on the human CNS produced either by eosinophils or possibly by eosinophil-derived neurotoxins.

AB - A 66-year-old woman with hypereosinophilic syndrome became rapidly demented. Evaluation revealed CSF eosinophilia, background slowing on EEG, and periventricular MRI abnormalities. Following steroid therapy, there was rapid resolution of the dementia and normalization of CSF and EEG. These findings support the concept of a direct neurotoxic effect on the human CNS produced either by eosinophils or possibly by eosinophil-derived neurotoxins.

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Reversible dementia with idiopathic hypereosinophilic syndrome

Abstract

ASJC Scopus subject areas

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