Reverse engineering the mouse brain

Daniel H. O'Connor, Daniel Huber, Karel Svoboda

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations

Abstract

Behaviour is governed by activity in highly structured neural circuits. Genetically targeted sensors and switches facilitate measurement and manipulation of activity in vivo, linking activity in defined nodes of neural circuits to behaviour. Because of access to specific cell types, these molecular tools will have the largest impact in genetic model systems such as the mouse. Emerging assays of mouse behaviour are beginning to rival those of behaving monkeys in terms of stimulus and behavioural control. We predict that the confluence of new behavioural and molecular tools in the mouse will reveal the logic of complex mammalian circuits.

Original languageEnglish (US)
Pages (from-to)923-929
Number of pages7
JournalNature
Volume461
Issue number7266
DOIs
StatePublished - Oct 15 2009
Externally publishedYes

ASJC Scopus subject areas

  • General

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