Reversal of protamine-induced catastrophic pulmonary vasoconstriction by prostaglandin E1

Glenn J.R. Whitman; Douglas Martel; Michael Weiss; Aura Pochanapring; W. Michael See; Alan Hopeman; Alden H. Harken; Ira M. Dauber

doi:10.1016/0003-4975(90)90758-X

Reversal of protamine-induced catastrophic pulmonary vasoconstriction by prostaglandin E₁

Glenn J.R. Whitman, Douglas Martel, Michael Weiss, Aura Pochanapring, W. Michael See, Alan Hopeman, Alden H. Harken, Ira M. Dauber

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E₁ is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E₁ is proposed.

Original language	English (US)
Pages (from-to)	303-305
Number of pages	3
Journal	The Annals of thoracic surgery
Volume	50
Issue number	2
DOIs	https://doi.org/10.1016/0003-4975(90)90758-X
State	Published - Aug 1990
Externally published	Yes

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1016/0003-4975(90)90758-X

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abstract = "A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.",

author = "Whitman, {Glenn J.R.} and Douglas Martel and Michael Weiss and Aura Pochanapring and See, {W. Michael} and Alan Hopeman and Harken, {Alden H.} and Dauber, {Ira M.}",

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AU - Whitman, Glenn J.R.

AU - Martel, Douglas

AU - Weiss, Michael

AU - Pochanapring, Aura

AU - See, W. Michael

AU - Hopeman, Alan

AU - Harken, Alden H.

AU - Dauber, Ira M.

PY - 1990/8

Y1 - 1990/8

N2 - A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.

AB - A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.

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Reversal of protamine-induced catastrophic pulmonary vasoconstriction by prostaglandin E₁

Abstract

ASJC Scopus subject areas

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