Retrospective Study of Nasal Infantile Hemangiomas: Characteristics, Complications, and Outcomes

Maria S. Kryatova, Barbara M. Rainer, Jiawei Zhao, Vadim A. Villarroel, Anna Yasmine Kirkorian, Anna L. Grossberg, Katherine B. Puttgen, Bernard A. Cohen

Research output: Contribution to journalArticlepeer-review


Background/Objectives: Nasal infantile hemangiomas (IHs) pose serious medical complications and psychosocial stress if tumor involution is incomplete or prolonged. The objective was to determine which IH characteristics are associated with complications and are predictive of outcome, assessed as the presence of IHs or residual skin changes upon kindergarten entry, to better manage these lesions and counsel families. Methods: A retrospective chart review of all patients seen in the Division of Pediatric Dermatology at Johns Hopkins Medicine between 2001 and 2014 for nasal IHs (N = 89) was performed. A follow-up telephone interview with parents was conducted in June and July 2014. Results: Complications were observed in 39% of patients. Segmental and indeterminate IHs were more likely to have complications than focal IHs (p = 0.01). Mixed IHs were more likely to ulcerate than deep or superficial IHs (p = 0.01). Eighty percent of patients had treatment and 19% had surgery. Although IHs regressed by kindergarten entry in 70% of patients, 78% of these patients had residual skin changes. Mixed and superficial IHs left more residua than deep IHs (p = 0.04). A statistical comparison of treatments with respect to outcome at kindergarten entry could not be made because subgroups were too small and heterogeneous. Conclusion: Nasal IHs had higher rates of complications and treatment than previous reports of IHs at all body sites. Lesions of segmental and indeterminate type and mixed depth should be identified as high risk and treated accordingly. Parents may be counseled that most nasal IHs involute by kindergarten but leave residua and that early referral for treatment may be important for the best outcome.

Original languageEnglish (US)
Pages (from-to)652-658
Number of pages7
JournalPediatric Dermatology
Issue number6
StatePublished - Nov 1 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Dermatology


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