Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: A case series

Omar Al-Louzi; Julia Button; Scott D. Newsome; Peter A. Calabresi; Shiv Saidha

doi:10.1177/1352458516679035

Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: A case series

Omar Al-Louzi, Julia Button, Scott D. Newsome, Peter A. Calabresi, Shiv Saidha

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Background: Trans-synaptic degeneration (TSD) describes the propagation of neuronal injury through synaptic pathways in the human nervous system and may be linked to the accelerated retinal atrophy seen in multiple sclerosis (MS). Results: We report six cases where homonymous, hemi-macular ganglion cell + inner plexiform (GCIP) thickness reduction was seen in conjunction with posterior visual pathway lesions. Macular microcystoid changes of the inner nuclear layer (INL) were seen in a subset of three subjects. Conclusion: Our findings highlight the utility of assessing regional GCIP changes to identify potential retrograde TSD in MS and demonstrate that INL changes may be an accompaniment in such instances.

Original language	English (US)
Pages (from-to)	1035-1039
Number of pages	5
Journal	Multiple Sclerosis
Volume	23
Issue number	7
DOIs	https://doi.org/10.1177/1352458516679035
State	Published - Jun 1 2017

Keywords

MRI
Relapsing/remitting
T2 lesions
atrophy
optical coherence tomography
retina

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: A case series",

abstract = "Background: Trans-synaptic degeneration (TSD) describes the propagation of neuronal injury through synaptic pathways in the human nervous system and may be linked to the accelerated retinal atrophy seen in multiple sclerosis (MS). Results: We report six cases where homonymous, hemi-macular ganglion cell + inner plexiform (GCIP) thickness reduction was seen in conjunction with posterior visual pathway lesions. Macular microcystoid changes of the inner nuclear layer (INL) were seen in a subset of three subjects. Conclusion: Our findings highlight the utility of assessing regional GCIP changes to identify potential retrograde TSD in MS and demonstrate that INL changes may be an accompaniment in such instances.",

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T2 - A case series

AU - Al-Louzi, Omar

AU - Button, Julia

AU - Newsome, Scott D.

AU - Calabresi, Peter A.

AU - Saidha, Shiv

N1 - Publisher Copyright: © SAGE Publications.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Trans-synaptic degeneration (TSD) describes the propagation of neuronal injury through synaptic pathways in the human nervous system and may be linked to the accelerated retinal atrophy seen in multiple sclerosis (MS). Results: We report six cases where homonymous, hemi-macular ganglion cell + inner plexiform (GCIP) thickness reduction was seen in conjunction with posterior visual pathway lesions. Macular microcystoid changes of the inner nuclear layer (INL) were seen in a subset of three subjects. Conclusion: Our findings highlight the utility of assessing regional GCIP changes to identify potential retrograde TSD in MS and demonstrate that INL changes may be an accompaniment in such instances.

AB - Background: Trans-synaptic degeneration (TSD) describes the propagation of neuronal injury through synaptic pathways in the human nervous system and may be linked to the accelerated retinal atrophy seen in multiple sclerosis (MS). Results: We report six cases where homonymous, hemi-macular ganglion cell + inner plexiform (GCIP) thickness reduction was seen in conjunction with posterior visual pathway lesions. Macular microcystoid changes of the inner nuclear layer (INL) were seen in a subset of three subjects. Conclusion: Our findings highlight the utility of assessing regional GCIP changes to identify potential retrograde TSD in MS and demonstrate that INL changes may be an accompaniment in such instances.

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KW - T2 lesions

KW - atrophy

KW - optical coherence tomography

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Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: A case series

Abstract

Keywords

ASJC Scopus subject areas

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