Retrograde trans-synaptic visual pathway degeneration in multiple sclerosis: A case series

Omar Al-Louzi, Julia Button, Scott D. Newsome, Peter A. Calabresi, Shiv Saidha

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Trans-synaptic degeneration (TSD) describes the propagation of neuronal injury through synaptic pathways in the human nervous system and may be linked to the accelerated retinal atrophy seen in multiple sclerosis (MS). Results: We report six cases where homonymous, hemi-macular ganglion cell + inner plexiform (GCIP) thickness reduction was seen in conjunction with posterior visual pathway lesions. Macular microcystoid changes of the inner nuclear layer (INL) were seen in a subset of three subjects. Conclusion: Our findings highlight the utility of assessing regional GCIP changes to identify potential retrograde TSD in MS and demonstrate that INL changes may be an accompaniment in such instances.

Original languageEnglish (US)
Pages (from-to)1035-1039
Number of pages5
JournalMultiple Sclerosis
Issue number7
StatePublished - Jun 1 2017


  • MRI
  • Relapsing/remitting
  • T2 lesions
  • atrophy
  • optical coherence tomography
  • retina

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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