Retinoic acid modulates retinoid X receptor α and retinoic acid receptor α levels of cultured brown adipocytes

M. Luisa Bonet; Pere Puigserver; Francisca Serra; Joan Ribot; Francisca Vázquez; Catalina Picó; Andreu Palou

doi:10.1016/S0014-5793(97)00274-3

Retinoic acid modulates retinoid X receptor α and retinoic acid receptor α levels of cultured brown adipocytes

M. Luisa Bonet, Pere Puigserver, Francisca Serra, Joan Ribot, Francisca Vázquez, Catalina Picó, Andreu Palou

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A novel potential regulatory pathway of brown adipose tissue (BAT) thermogenesis was recently recognized after identifying retinoic acid (RA) as a transcriptional activator of the uncoupling protein (UCP) gene. Here we provide evidence that the UCP responsiveness to RA in primary cultures of brown adipocytes involves RA receptor α (RARα), and show, in the same system and also in CHO cells, that RA down-regulates the steady-state levels of RARα and especially of retinoid X receptor α, suggesting autoregulation of the retinoid pathway and therefore supporting the idea of a physiological role for it in controlling the thermogenic capacity of BAT.

Original language	English (US)
Pages (from-to)	196-200
Number of pages	5
Journal	FEBS Letters
Volume	406
Issue number	1-2
DOIs	https://doi.org/10.1016/S0014-5793(97)00274-3
State	Published - Apr 7 1997
Externally published	Yes

Keywords

Cultured brown adipocytes
Retinoic acid
Retinoic acid receptor α
Retinoid X receptor α
Uncoupling protein

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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10.1016/S0014-5793(97)00274-3

Cite this

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title = "Retinoic acid modulates retinoid X receptor α and retinoic acid receptor α levels of cultured brown adipocytes",

abstract = "A novel potential regulatory pathway of brown adipose tissue (BAT) thermogenesis was recently recognized after identifying retinoic acid (RA) as a transcriptional activator of the uncoupling protein (UCP) gene. Here we provide evidence that the UCP responsiveness to RA in primary cultures of brown adipocytes involves RA receptor α (RARα), and show, in the same system and also in CHO cells, that RA down-regulates the steady-state levels of RARα and especially of retinoid X receptor α, suggesting autoregulation of the retinoid pathway and therefore supporting the idea of a physiological role for it in controlling the thermogenic capacity of BAT.",

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AU - Bonet, M. Luisa

AU - Puigserver, Pere

AU - Serra, Francisca

AU - Ribot, Joan

AU - Vázquez, Francisca

AU - Picó, Catalina

AU - Palou, Andreu

PY - 1997/4/7

Y1 - 1997/4/7

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AB - A novel potential regulatory pathway of brown adipose tissue (BAT) thermogenesis was recently recognized after identifying retinoic acid (RA) as a transcriptional activator of the uncoupling protein (UCP) gene. Here we provide evidence that the UCP responsiveness to RA in primary cultures of brown adipocytes involves RA receptor α (RARα), and show, in the same system and also in CHO cells, that RA down-regulates the steady-state levels of RARα and especially of retinoid X receptor α, suggesting autoregulation of the retinoid pathway and therefore supporting the idea of a physiological role for it in controlling the thermogenic capacity of BAT.

KW - Cultured brown adipocytes

KW - Retinoic acid

KW - Retinoic acid receptor α

KW - Retinoid X receptor α

KW - Uncoupling protein

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Retinoic acid modulates retinoid X receptor α and retinoic acid receptor α levels of cultured brown adipocytes

Abstract

Keywords

ASJC Scopus subject areas

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