TY - JOUR
T1 - Retinal Vessels Change in Primary Angle-Closure Glaucoma
T2 - The Handan Eye Study
AU - Gao, Jianlu
AU - Liang, Yuanbo
AU - Wang, Fenghua
AU - Shen, Ran
AU - Wong, Tienyin
AU - Peng, Yi
AU - Friedman, David S.
AU - Wang, Ningli
N1 - Funding Information:
This study was supported by National Basic Research Program of China (973 Program) Grant 2007CB512201 from the Ministry of Science &Technology of the People’s Republic of China; program of Health Policy for Blindness Prevention from Ministry of Health the People’s Republic of China; Key Technologies R&D Program (No. 2006–10903) from Bureau of Science and Technology of Handan city, Hebei Province, China; Beijing Tongren Hospital and the Key discipline fund of Bureau of Health, Handan city, Hebei Province, China.
PY - 2015/4/30
Y1 - 2015/4/30
N2 - Glaucoma is the second leading cause of blindness worldwide. To examine the relationship between angle closure and the retinal vessel diameter in Chinese adults, we conducted Handan Eye Study (HES), a large population-based cross-sectional study, which enrolled 6830 participants >30 year-old living in 13 randomly selected villages of Yongnian County. After adjusting for age, gender, spherical equivalent (SE), diabetes, and hypertension, the mean central retinal artery equivalent (CRAE, Î 1/4m) was 127.1 ± 7.0 and 145.6 ± 4.4 in primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG), respectively; narrower than that in normal control (156.1 ± 0.4), primary angle-closure suspect (PACS) (156.3 ± 1.1) or primary angle closure (PAC) (156.0 ± 3.4) (P = 0.001). The mean central retinal vein equivalent (CRVE, Î 1/4m) was 229.0 ± 5.9 and 215.8 ± 9.5 in POAG and PACG, respectively; narrower than that in normal control (238.3 ± 0.5), PACS (241.2 ± 1.4) or PAC (242.2 ± 4.6) (P = 0.001). There was no significant difference in the mean CRAE or CRVE between PACG and POAG. Compared to the normal control (0.66), the mean arterio-venous ratio (AVR) was smaller in POAG (0.64) and PACG (0.59), whereas larger in PACS (0.65) and PAC (0.67) (P = 0.003). To conclude, PACG and POAG individuals have narrower retinal arteries and veins.
AB - Glaucoma is the second leading cause of blindness worldwide. To examine the relationship between angle closure and the retinal vessel diameter in Chinese adults, we conducted Handan Eye Study (HES), a large population-based cross-sectional study, which enrolled 6830 participants >30 year-old living in 13 randomly selected villages of Yongnian County. After adjusting for age, gender, spherical equivalent (SE), diabetes, and hypertension, the mean central retinal artery equivalent (CRAE, Î 1/4m) was 127.1 ± 7.0 and 145.6 ± 4.4 in primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG), respectively; narrower than that in normal control (156.1 ± 0.4), primary angle-closure suspect (PACS) (156.3 ± 1.1) or primary angle closure (PAC) (156.0 ± 3.4) (P = 0.001). The mean central retinal vein equivalent (CRVE, Î 1/4m) was 229.0 ± 5.9 and 215.8 ± 9.5 in POAG and PACG, respectively; narrower than that in normal control (238.3 ± 0.5), PACS (241.2 ± 1.4) or PAC (242.2 ± 4.6) (P = 0.001). There was no significant difference in the mean CRAE or CRVE between PACG and POAG. Compared to the normal control (0.66), the mean arterio-venous ratio (AVR) was smaller in POAG (0.64) and PACG (0.59), whereas larger in PACS (0.65) and PAC (0.67) (P = 0.003). To conclude, PACG and POAG individuals have narrower retinal arteries and veins.
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U2 - 10.1038/srep09585
DO - 10.1038/srep09585
M3 - Article
C2 - 25928115
AN - SCOPUS:84946186995
SN - 2045-2322
VL - 5
JO - Scientific reports
JF - Scientific reports
M1 - 9585
ER -