Retinal vascular changes and systemic diseases: corrosion cast demonstration.

T. Amemiya, I. A. Bhutto

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The purpose of the present study is to clarify the specific retinal vascular changes in rat models of single spontaneous or hereditary systemic diseases. We used Wistar Kyoto (WKy) rats 6 months of age as normal controls, 24-month-old Wistar Kyoto rats in studies of aging, 16-month-old spontaneously hypertensive rats (SHR), 18-month-old rats with inherited hypercholesterolemia (RICO) for arteriosclerosis, and 18-month-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats for diabetes mellitus. Retinal vascular corrosion casts were made and observed with a scanning electron microscope. The retinal vessels were also examined with a transmission electron microscope. Specific changes in the retinal vessels were: narrowing and thin thread-like capillaries in aging; capillary tortuosity, irregularity and narrowing in hypertension; straightening in hypercholesterolemia; and loop formation and microaneurysms in diabetes mellitus. These specific changes in the retinal vessels in each systemic disease can be clearly and easily revealed in a three-dimensional fashion by corrosion casts followed by scanning electron microscopy.

Original languageEnglish (US)
Pages (from-to)237-244
Number of pages8
JournalItalian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia
Issue number2 Suppl 1
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Embryology


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