Retinal Pigment Epithelial Cells Release An Inhibitor Of Neovascularization

Bert M. Glaser; Peter A. Campochiaro; John L. Davis; Misao Sato

doi:10.1001/archopht.1985.01050120104029

Retinal Pigment Epithelial Cells Release An Inhibitor Of Neovascularization

Bert M. Glaser, Peter A. Campochiaro, John L. Davis, Misao Sato

School of Medicine

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts, under identical test conditions, released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human retinal pigment epithelial cells released higher levels of inhibitor than confluent cultures.

Original language	English (US)
Pages (from-to)	1870-1875
Number of pages	6
Journal	Archives of ophthalmology
Volume	103
Issue number	12
DOIs	https://doi.org/10.1001/archopht.1985.01050120104029
State	Published - Dec 1985

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1985.01050120104029

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abstract = "Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts, under identical test conditions, released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human retinal pigment epithelial cells released higher levels of inhibitor than confluent cultures.",

author = "Glaser, {Bert M.} and Campochiaro, {Peter A.} and Davis, {John L.} and Misao Sato",

year = "1985",

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AU - Glaser, Bert M.

AU - Campochiaro, Peter A.

AU - Davis, John L.

AU - Sato, Misao

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Y1 - 1985/12

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AB - Human retinal pigment epithelial cells in culture were found to release a substance (or substances) that causes the regression of new blood vessels on the chick embryonic yolk sac and inhibits proliferation of fetal bovine aortic endothelial cells in vitro. Neither astrocytes nor fibroblasts, under identical test conditions, released detectable inhibitors of neovascularization or endothelial cell growth. Subconfluent and superconfluent cultures of human retinal pigment epithelial cells released higher levels of inhibitor than confluent cultures.

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Retinal Pigment Epithelial Cells Release An Inhibitor Of Neovascularization

Abstract

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