Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates

Caeul Lim, Ligia Pereira, Kathryn Shaw Saliba, Anjali Mascarenhas, Jennifer N. Maki, Laura Chery, Edwin Gomes, Pradipsinh K. Rathod, Manoj T. Duraisingh

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Plasmodium vivax, the most widely distributed human malaria parasite, is restricted to reticulocytes, limiting its asexual proliferation. In recent years, cases of severe and high-level P. vivax parasitemia have been reported, challenging the assumption that all isolates are equally restricted. In this article, we analyze the reticulocyte preference of a large number of Indian P. vivax isolates. Our results show that P. vivax isolates significantly vary in their level of reticulocyte preference. In addition, by carefully staging the parasites, we find that P. vivax schizonts are largely missing in peripheral blood, with the presence of schizonts in circulation correlating with a high reticulocyte preference.

Original languageEnglish (US)
Pages (from-to)1081-1084
Number of pages4
JournalJournal of Infectious Diseases
Issue number7
StatePublished - Oct 1 2016


  • Plasmodium vivax
  • asexual stage
  • reticulocyte preference

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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