Retained cocaine conditioned place preference in D1 receptor deficient mice

Lucinda L. Miner, John Drago, Paul M. Chamberlain, David Donovan, George R. Uhl

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


The role of the D1 dopamine receptor subtype in mediating cocaine effects was examined in mice in which the D1 receptor gene had been ablated by homologous recombination. Cocaine reward was assessed by conditioned place preference experiments using mice which had either one allele (+/-) or both alleles (-/-) of the D1 dopamine receptor gene disrupted and in their wild type (+/+) littermates. Cocaine conditioning resulted in similar increases in preference for drug-paired environments in mice of each of the three genotypes. Cocaine did not alter locomotor activity levels in homozygous, D1 knockout mice -/-, whereas increased activity was noted in both +/+ and +/- animals. These results are consistent with the idea that the D1 receptor is involved in the locomotor stimulant effects of cocaine, but has little role in a major test of the rewarding and reinforcing effects of the drug.

Original languageEnglish (US)
Pages (from-to)2314-2316
Number of pages3
Issue number17
StatePublished - Nov 27 1995


  • Cocaine
  • Conditioned place preference
  • D1 dopamine receptor
  • Homologous recombination

ASJC Scopus subject areas

  • Neuroscience(all)


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