TY - JOUR
T1 - Resting-state networks as simultaneously measured with functional MRI and PET
AU - Savio, Alexandre
AU - Fünger, Sarah
AU - Tahmasian, Masoud
AU - Rachakonda, Srinivas
AU - Manoliu, Andrei
AU - Sorg, Christian
AU - Grimmer, Timo
AU - Calhoun, Vince
AU - Drzezga, Alexander
AU - Riedl, Valentin
AU - Yakushev, Igor
N1 - Publisher Copyright:
© Copyright 2017 by the Society of Nuclear MeDicine and Molecular Imaging.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Functional MRI (fMRI) stuDies reported Disruption of resting-state networks (RSNs) in several neuropsychiatric Disorders. PET with 18F-FDG captures neuronal activity that is in steady state at a longer time span and is less dependent on neurovascular coupling. Methods: In the present study, we aimed to identify RSNs in 18F-FDG PET data and compare their spatial pattern with those obtained from simultaneously acquired resting-state fMRI data in 22 middle-aged healthy subjects. Results: Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair tomoderate for the defaultmode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auDitory networks. Despite recorDing Different aspects of neural activity, similar RSNs were detected by both imaging modalities. Conclusion: The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET data.
AB - Functional MRI (fMRI) stuDies reported Disruption of resting-state networks (RSNs) in several neuropsychiatric Disorders. PET with 18F-FDG captures neuronal activity that is in steady state at a longer time span and is less dependent on neurovascular coupling. Methods: In the present study, we aimed to identify RSNs in 18F-FDG PET data and compare their spatial pattern with those obtained from simultaneously acquired resting-state fMRI data in 22 middle-aged healthy subjects. Results: Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair tomoderate for the defaultmode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auDitory networks. Despite recorDing Different aspects of neural activity, similar RSNs were detected by both imaging modalities. Conclusion: The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET data.
KW - Brain connectivity
KW - Glucose metabolism
KW - Independent component analysis
KW - Multimodal imaging
KW - Positron emission tomography
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U2 - 10.2967/jnumed.116.185835
DO - 10.2967/jnumed.116.185835
M3 - Article
C2 - 28254868
AN - SCOPUS:85026387094
SN - 0161-5505
VL - 58
SP - 1314
EP - 1317
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 8
ER -