Resting-state networks as simultaneously measured with functional MRI and PET

Alexandre Savio, Sarah Fünger, Masoud Tahmasian, Srinivas Rachakonda, Andrei Manoliu, Christian Sorg, Timo Grimmer, Vince Calhoun, Alexander Drzezga, Valentin Riedl, Igor Yakushev

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Functional MRI (fMRI) stuDies reported Disruption of resting-state networks (RSNs) in several neuropsychiatric Disorders. PET with 18F-FDG captures neuronal activity that is in steady state at a longer time span and is less dependent on neurovascular coupling. Methods: In the present study, we aimed to identify RSNs in 18F-FDG PET data and compare their spatial pattern with those obtained from simultaneously acquired resting-state fMRI data in 22 middle-aged healthy subjects. Results: Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair tomoderate for the defaultmode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auDitory networks. Despite recorDing Different aspects of neural activity, similar RSNs were detected by both imaging modalities. Conclusion: The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET data.

Original languageEnglish (US)
Pages (from-to)1314-1317
Number of pages4
JournalJournal of Nuclear Medicine
Issue number8
StatePublished - Aug 1 2017


  • Brain connectivity
  • Glucose metabolism
  • Independent component analysis
  • Multimodal imaging
  • Positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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