Responsiveness of the EQ-5D to the effects of low vision rehabilitation

Alexis G. Malkin, Judith E. Goldstein, Monica S. Perlmutter, Robert W. Massof

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


PURPOSE: This study is an evaluation of the responsiveness of preference-based outcome measures to the effects of low vision rehabilitation (LVR). It assesses LVR-related changes in EQ-5D utilities in patients who exhibit changes in Activity Inventory (AI) measures of visual ability. METHODS: Telephone interviews were conducted on 77 low-vision patients out of a total of 764 patients in the parent study of "usual care" in LVR. Activity Inventory results were filtered for each patient to include only goals and tasks that would be targeted by LVR. RESULTS: The EQ-5D utilities have weak correlations with all AI measures but correlate best with AI goal scores at baseline (r = 0.48). Baseline goal scores are approximately normally distributed for the AI, but EQ-5D utilities at baseline are skewed toward the ceiling (median, 0.77). Effect size for EQ-5D utility change scores from pre- to post-LVR was not significantly different from zero. The AI visual function ability change scores corresponded to a moderate effect size for all functional domains and a large effect size for visual ability measures estimated from AI goal ratings. CONCLUSIONS: This study found that the EQ-5D is unresponsive as an outcome measure for LVR and has poor sensitivity for discriminating low vision patients with different levels of ability.

Original languageEnglish (US)
Pages (from-to)799-805
Number of pages7
JournalOptometry and Vision Science
Issue number8
StatePublished - Aug 2013


  • EQ-5D
  • low vision
  • outcome measures
  • utility
  • visual function

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry


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