Response to comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

Sanaz Eftekhari; Amene Shahrokhi; Vera Tsintsadze; Romain Nardou; Corinne Brouchoud; Magali Conesa; Nail Burnashev; Diana C. Ferrari; Yehezkel Ben-Ari

doi:10.1126/science.1256009

Response to comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

Sanaz Eftekhari, Amene Shahrokhi, Vera Tsintsadze, Romain Nardou, Corinne Brouchoud, Magali Conesa, Nail Burnashev, Diana C. Ferrari, Yehezkel Ben-Ari

Research output: Contribution to journal › Article › peer-review

Abstract

Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.

Original language	English (US)
Article number	176
Journal	Science
Volume	346
Issue number	6206
DOIs	https://doi.org/10.1126/science.1256009
State	Published - Oct 10 2014
Externally published	Yes

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abstract = "Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.",

author = "Sanaz Eftekhari and Amene Shahrokhi and Vera Tsintsadze and Romain Nardou and Corinne Brouchoud and Magali Conesa and Nail Burnashev and Ferrari, {Diana C.} and Yehezkel Ben-Ari",

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AU - Eftekhari, Sanaz

AU - Shahrokhi, Amene

AU - Tsintsadze, Vera

AU - Nardou, Romain

AU - Brouchoud, Corinne

AU - Conesa, Magali

AU - Burnashev, Nail

AU - Ferrari, Diana C.

AU - Ben-Ari, Yehezkel

PY - 2014/10/10

Y1 - 2014/10/10

N2 - Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.

AB - Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.

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JO - Science

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Response to comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

Abstract

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