Response to comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring"

Sanaz Eftekhari, Amene Shahrokhi, Vera Tsintsadze, Romain Nardou, Corinne Brouchoud, Magali Conesa, Nail Burnashev, Diana C. Ferrari, Yehezkel Ben-Ari

Research output: Contribution to journalArticlepeer-review

Abstract

Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.

Original languageEnglish (US)
Article number176
JournalScience
Volume346
Issue number6206
DOIs
StatePublished - Oct 10 2014
Externally publishedYes

ASJC Scopus subject areas

  • General

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