TY - JOUR
T1 - Respiratory tract rather than cutaneous atopic allergy inversely associate with multiple sclerosis
T2 - A case-control study
AU - Sahraian, Mohammad Ali
AU - Jafarian, Sirous
AU - Sheikhbahaei, Sara
AU - Safavi, Farinaz
PY - 2013/10
Y1 - 2013/10
N2 - Background It has been previously shown that genetic or environmental factors, which promote susceptibility to allergic conditions, prevent the development of Th1-mediated inflammatory disease of multiple sclerosis (MS). To investigate the prediction value of lifetime atopic allergy in development of the future MS, a case-control study was designed. Methods Cases and controls were interviewed between December 2007 and April 2008 and they were asked if they had symptoms or diagnosis of allergies (including respiratory tract allergy, RTA; coetaneous allergy, CA; food/drug allergy, FDA) before MS diagnosis. Results Of 390 participants (195 controls and 195 cases), 125 healthy controls (64.1%) and 105 cases (53.8%) reported history of at least one type of atopic allergy (P = 0.04). A positive history of RTA (OR 0.43; 95% CI 0.28-0.66) or FDA (OR 0.24; 95% CI 0.13-0.43) was inversely associated with the risk of MS. No statistically significant association was found between the history of CA and MS. Conclusions There is a significant inverse association between RTA and MS that is compatible with a Th1/Th2 imbalance. History of RTA can be considered as a clinically useful risk reducing factor of MS.
AB - Background It has been previously shown that genetic or environmental factors, which promote susceptibility to allergic conditions, prevent the development of Th1-mediated inflammatory disease of multiple sclerosis (MS). To investigate the prediction value of lifetime atopic allergy in development of the future MS, a case-control study was designed. Methods Cases and controls were interviewed between December 2007 and April 2008 and they were asked if they had symptoms or diagnosis of allergies (including respiratory tract allergy, RTA; coetaneous allergy, CA; food/drug allergy, FDA) before MS diagnosis. Results Of 390 participants (195 controls and 195 cases), 125 healthy controls (64.1%) and 105 cases (53.8%) reported history of at least one type of atopic allergy (P = 0.04). A positive history of RTA (OR 0.43; 95% CI 0.28-0.66) or FDA (OR 0.24; 95% CI 0.13-0.43) was inversely associated with the risk of MS. No statistically significant association was found between the history of CA and MS. Conclusions There is a significant inverse association between RTA and MS that is compatible with a Th1/Th2 imbalance. History of RTA can be considered as a clinically useful risk reducing factor of MS.
KW - Atopic hypersensitivity
KW - Eczema
KW - Food hypersensitivity
KW - Multiple sclerosis
KW - Respiratory hypersensitivity
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U2 - 10.1016/j.clineuro.2013.07.028
DO - 10.1016/j.clineuro.2013.07.028
M3 - Article
C2 - 23958049
AN - SCOPUS:84884535271
SN - 0303-8467
VL - 115
SP - 2099
EP - 2102
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 10
ER -