Respiratory therapies for amyotrophic lateral sclerosis: A primer

Kirsten L. Gruis, Noah Lechtzin

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Respiratory complications are a common cause of morbidity and mortality in amyotrophic lateral sclerosis (ALS). Treatment of respiratory insufficiency with noninvasive ventilation (NIV) improves ALS patients' quality of life and survival. Evidence-based practice guidelines for the management of ALS patients recommend treatment of respiratory insufficiency with NIV as well as consideration of insufflation/exsufflation to improve clearance of airway secretions. Despite these recommendations respiratory therapies remain underused. In this review we provide a practical guide for the clinician to prescribe and manage respiratory therapies for the patient with ALS.

Original languageEnglish (US)
Pages (from-to)313-331
Number of pages19
JournalMuscle and Nerve
Issue number3
StatePublished - Sep 2012


  • Amyotrophic lateral sclerosis
  • Mechanical insufflation-exsufflation
  • Noninvasive ventilation
  • Practical guide
  • Respiratory therapy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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