Resource allocation for controlling epidemics: Calibrating, analyzing, and optimizing an agent-based simulation

Parastu Kasaie, W. David Kelton

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


This is a companion article to Kasaie and Kelton (2013), and provides an extended discussion on the calibration, analysis, and optimization of an agent-based simulation (ABS) model of an epidemic. The detailed information is presented for the illustrative case of a resource-allocation (RA) problem in the control of an influenza pandemic as described in Section 4 of Kasaie and Kelton (2013). The suggested protocol, however, can be adapted to address other instances of the RA problem in the context of other infectious disease epidemics. Section 1 defines all the parameters and run conditions for the ABS model. In Section 2 we discuss calibration of the RA objective function (DALYs function) and related sensitivity analyses. An investigation of variance reduction for the ABS model is presented in Section 3. A short discussion on application of mixture design and the corresponding triangular output displays for this design is discussed in Section 4. Finally, Section 5 presents the numerical results of the RA problem using a response surface methodology optimization approach.

Original languageEnglish (US)
Pages (from-to)94-109
Number of pages16
JournalIIE Transactions on Healthcare Systems Engineering
Issue number2
StatePublished - 2013
Externally publishedYes


  • Epidemic simulation modeling
  • resource allocation
  • response-surface methodology
  • simulation optimization

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Safety, Risk, Reliability and Quality
  • Safety Research


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