Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns

Susan H. Eshleman; Donald R. Hoover; Shu Chen; Sarah E. Hudelson; Laura A. Guay; Anthony Mwatha; Susan A. Fiscus; Francis Mmiro; Philippa Musoke; J. Brooks Jackson; Newton Kumwenda; Taha Taha

doi:10.1097/01.aids.0000194800.43799.94

Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns

Susan H. Eshleman, Donald R. Hoover, Shu Chen, Sarah E. Hudelson, Laura A. Guay, Anthony Mwatha, Susan A. Fiscus, Francis Mmiro, Philippa Musoke, J. Brooks Jackson, Newton Kumwenda, Taha Taha

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89 Scopus citations

Abstract

The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants -who -were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).

Original language	English (US)
Pages (from-to)	2167-2169
Number of pages	3
Journal	AIDS
Volume	19
Issue number	18
DOIs	https://doi.org/10.1097/01.aids.0000194800.43799.94
State	Published - Dec 2005

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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title = "Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns",

abstract = "The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants -who -were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).",

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T1 - Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns

AU - Eshleman, Susan H.

AU - Hoover, Donald R.

AU - Chen, Shu

AU - Hudelson, Sarah E.

AU - Guay, Laura A.

AU - Mwatha, Anthony

AU - Fiscus, Susan A.

AU - Mmiro, Francis

AU - Musoke, Philippa

AU - Jackson, J. Brooks

AU - Kumwenda, Newton

AU - Taha, Taha

PY - 2005/12

Y1 - 2005/12

N2 - The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants -who -were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).

AB - The administration of single-dose nevirapine to women in labor and their infants can prevent HIV-1 mother-to-child transmission. We examined nevirapine resistance in infants -who -were HIV-1 infected despite single-dose nevirapine prophylaxis, including 18 Ugandan infants (HIVNET 012 trial, nine subtype A and nine subtype D) and 23 Malawian infants (NVAZ trial, all subtype C). Nevirapine resistance was more frequent in infants with subtype C than with subtypes A and D (87 versus 50%, P = 0.016).

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Resistance after single-dose nevirapine prophylaxis emerges in a high proportion of Malawian newborns

Abstract

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