Residual risk in statin-treated patients: Future therapeutic options

Catherine Y. Campbell, Juan J. Rivera, Roger S. Blumenthal

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Statin therapy for aggressive low-density lipoprotein cholesterol (LDL-C) reduction reduces cardiovascular morbidity and mortality. However, even on maximal statin therapy, high-risk patients have substantial residual risk of coronary heart disease (CHD). Certain subgroups, such as individuals with diabetes mellitus, low high-density lipoprotein cholesterol (HDL-C), metabolic syndrome, or other comorbidities, have a particularly high residual risk. Patients at high risk for future CHD events often require multiple aggressive risk-reduction therapies (eg, antiplatelet agents, an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, β-blockade, cholesterol and/or diabetes management, and lifestyle interventions) to further lower their overall cardiovascular risk. For cholesterol management, combination therapy may be required to attain optimal levels of LDL-C, HDL-C, and non-HDL-C.

Original languageEnglish (US)
Pages (from-to)499-505
Number of pages7
JournalCurrent Cardiology Reports
Issue number6
StatePublished - Nov 1 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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