TY - JOUR
T1 - Research priorities for an HIV cure
T2 - International AIDS Society Global Scientific Strategy 2021
AU - Working Group 8: (Social, behavioral and ethical aspects of cure)
AU - The International AIDS Society (IAS) Global Scientific Strategy working group
AU - Core Leadership Group
AU - Working Group 1 (Understanding HIV reservoirs)
AU - Working Group 2 (HIV reservoir measurement)
AU - Working Group 3 (Mechanisms of virus control)
AU - Working Group 4 (Targeting the provirus)
AU - Working Group 5 (Targeting the immune system)
AU - Working Group 6 (Cell and gene therapy)
AU - Working Group 7 (Paediatric remission and cure)
AU - Deeks, Steven G.
AU - Archin, Nancie
AU - Cannon, Paula
AU - Collins, Simon
AU - Jones, R. Brad
AU - de Jong, Marein A.W.P.
AU - Lambotte, Olivier
AU - Lamplough, Rosanne
AU - Ndung’u, Thumbi
AU - Sugarman, Jeremy
AU - Tiemessen, Caroline T.
AU - Vandekerckhove, Linos
AU - Lewin, Sharon R.
AU - Deeks, Steven
AU - de Jong, Marein
AU - Ndhlovu, Zaza
AU - Chomont, Nicolas
AU - Brumme, Zabrina
AU - Deng, Kai
AU - Jasenosky, Luke
AU - Jefferys, Richard
AU - Orta-Resendiz, Aurelio
AU - Mardarelli, Frank
AU - Nijhuis, Monique
AU - Bar, Katharine
AU - Howell, Bonnie
AU - Schneider, Alex
AU - Turk, Gabriela
AU - Nabatanzi, Rose
AU - Blankson, Joel
AU - Garcia, J. Victor
AU - Paiardini, Mirko
AU - Lunzen, Jan van
AU - Antoniadi, Christina
AU - Côrtes, Fernanda Heloise
AU - Valente, Susana
AU - Søgaard, Ole S.
AU - Diaz, Ricardo Sobhie
AU - Ott, Melannie
AU - Dunham, Richard R.
AU - Schwarze, Siegfried
AU - Patrigeon, Santiago Perez
AU - Nabukenya, Josephine
AU - Caskey, Marina
AU - Mothe, Beatriz
AU - Wang, Fu Sheng
AU - Fidler, Sarah
AU - SenGupta, Devi
AU - Dressler, Stephan
AU - Persaud, Deborah
N1 - Publisher Copyright:
© 2021, Springer Nature America, Inc.
PY - 2021/12
Y1 - 2021/12
N2 - Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they are largely transcriptionally silent, but contain replication-competent virus that drives resurgence of the infection once ART is stopped. With a combination of immune activators, neutralizing antibodies, and therapeutic vaccines, some nonhuman primate models have been cured, providing optimism for these approaches now being evaluated in human clinical trials. In vivo delivery of gene-editing tools to either target the virus, boost immunity or protect cells from infection, also holds promise for future HIV cure strategies. In this Review, we discuss advances related to HIV cure in the last 5 years, highlight remaining knowledge gaps and identify priority areas for research for the next 5 years.
AB - Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. HIV can integrate in the host genome and persist for the life span of the infected cell. These latently infected cells are not recognized as foreign because they are largely transcriptionally silent, but contain replication-competent virus that drives resurgence of the infection once ART is stopped. With a combination of immune activators, neutralizing antibodies, and therapeutic vaccines, some nonhuman primate models have been cured, providing optimism for these approaches now being evaluated in human clinical trials. In vivo delivery of gene-editing tools to either target the virus, boost immunity or protect cells from infection, also holds promise for future HIV cure strategies. In this Review, we discuss advances related to HIV cure in the last 5 years, highlight remaining knowledge gaps and identify priority areas for research for the next 5 years.
UR - https://www.scopus.com/pages/publications/85122771062
UR - https://www.scopus.com/pages/publications/85122771062#tab=citedBy
U2 - 10.1038/s41591-021-01590-5
DO - 10.1038/s41591-021-01590-5
M3 - Review article
C2 - 34848888
AN - SCOPUS:85122771062
SN - 1078-8956
VL - 27
SP - 2085
EP - 2098
JO - Nature medicine
JF - Nature medicine
IS - 12
ER -