Republished: Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: Technical note

Michal Zawadzki; Jerzy Walecki; Boguslaw Kostkiewicz; Kacper Kostyra; Monica Smith Pearl; Meiyappan Solaiyappan; Piotr Walczak; Miroslaw Janowski

doi:10.1136/neurintsurg-2018-014469.rep

Republished: Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: Technical note

Michal Zawadzki, Jerzy Walecki, Boguslaw Kostkiewicz, Kacper Kostyra, Monica Smith Pearl, Meiyappan Solaiyappan, Piotr Walczak, Miroslaw Janowski

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.

Original language	English (US)
Pages (from-to)	E1
Journal	Journal of neurointerventional surgery
Volume	11
Issue number	8
DOIs	https://doi.org/10.1136/neurintsurg-2018-014469.rep
State	Published - Aug 1 2019

Keywords

MRI
brain
intervention
malignant
technique

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1136/neurintsurg-2018-014469.rep

Cite this

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title = "Republished: Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: Technical note",

abstract = "Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.",

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AU - Zawadzki, Michal

AU - Walecki, Jerzy

AU - Kostkiewicz, Boguslaw

AU - Kostyra, Kacper

AU - Pearl, Monica Smith

AU - Solaiyappan, Meiyappan

AU - Walczak, Piotr

AU - Janowski, Miroslaw

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.

AB - Patients suffering from malignant brain tumors are burdened with a grim prognosis. The blood brain barrier is considered a primary obstacle in therapeutic drug delivery to the brain. Intra-arterial (IA) delivery of therapeutic agents following osmotic BBB opening has been attempted for years, but high variability has limited its widespread implementation. It has been recently shown in animal studies that MRI is superior to X-ray for guiding IA infusions, as it allows direct visualization of the brain parenchyma perfused and facilitates predictable drug targeting. Moreover, PET imaging has revealed that IA, not intravenous, delivery of bevacizumab results in brain accumulation, providing strong rationale for utilizing the IA route. Here, we present our experience in a patient with recurrent butterfly glioblastoma enrolled in first-in-man MRI-guided neurointervention for targeted IA drug delivery.

KW - MRI

KW - brain

KW - intervention

KW - malignant

KW - technique

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Republished: Real-time MRI guidance for intra-arterial drug delivery in a patient with a brain tumor: Technical note

Abstract

Keywords

ASJC Scopus subject areas

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