TY - JOUR
T1 - Reproductive and marital experience of parents of children with Down's syndrome (mongolism)
AU - Sigler, Arnold T.
AU - Cohen, Bernice H.
AU - Lilienfeld, Abraham M.
AU - Westlake, Jeannette E.
AU - Hetznecker, William H.
N1 - Funding Information:
~Part of this study was perJormed while Dr. Sigler was assigned to the Research Branch, Division o[ Radiological Health United States Public Health Service. Address, Department of Pediatrics, The Johns Hopkins Hospital, Baltimore, Md. 21205 :-+~Dr. Lilienfeld is a recipien~ of a Research Career Award No. K6-GM-13901 and Dr. Cohen is a recipient of a Research Career Development Award No. K3-GA4-5590, both ]rom the National Institute o[ General Medical Sciences.
Funding Information:
Supported by United States Public Health Service, Research Branch, Division o[ Radiological Health, Contract No. SAph 76367, and in part by National Cancer Institute Grant No. CT 5085 and National Heart Institute Grant No. HE5297.
Funding Information:
Some o[ the computations in this paper were done in the Computing Center o[ the Johns Hopkins Medical Institutions, which is supported by Research Grant FR-O0004 from the National Institutes of Health.
PY - 1967/4
Y1 - 1967/4
N2 - An epidemiologic study of the parents and siblings of 216 children with Down's syndrome and of 216 control children matched on the basis of maternal age at the time of the child's birth demonstrated no differences in the frequencies of abortions, stillbirths, or congenital abnormalities, nor did the siblings of the children with Down's syndrome have a higher frequency of deaths from acquired causes than did the siblings of the controls. Mothers in the two groups were similar in fertility and there were no differences in their menstrual histories. A significantly higher frequency of multiple marriages prior to the birth of the index child was observed in the mothers of the affected children. Some possible interpretations of these observations are discussed.
AB - An epidemiologic study of the parents and siblings of 216 children with Down's syndrome and of 216 control children matched on the basis of maternal age at the time of the child's birth demonstrated no differences in the frequencies of abortions, stillbirths, or congenital abnormalities, nor did the siblings of the children with Down's syndrome have a higher frequency of deaths from acquired causes than did the siblings of the controls. Mothers in the two groups were similar in fertility and there were no differences in their menstrual histories. A significantly higher frequency of multiple marriages prior to the birth of the index child was observed in the mothers of the affected children. Some possible interpretations of these observations are discussed.
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U2 - 10.1016/S0022-3476(67)80046-5
DO - 10.1016/S0022-3476(67)80046-5
M3 - Article
C2 - 4225328
AN - SCOPUS:0014077355
SN - 0022-3476
VL - 70
SP - 608
EP - 614
JO - The Journal of pediatrics
JF - The Journal of pediatrics
IS - 4
ER -