Reproducibility of chronic infarct size measurement by contrast-enhanced magnetic resonance imaging

Heiko Mahrholdt, Anja Wagner, Thomas A. Holly, Michael D. Elliott, Robert O. Bonow, Raymond J. Kim, Robert M. Judd

Research output: Contribution to journalArticlepeer-review

324 Scopus citations


Background - The reproducibility of contrast-enhanced MRI has not been established. We compared MRI reproducibility for infarct size determination with that of 99mTc-sestamibi (MIBI) single photon emission computed tomography (SPECT). Methods and Results - Patients with chronic myocardial infarction defined by enzymes (peak creatine kinase-MB 173±119 U/L) were scanned twice by MRI (MRI I and MRI II, n=20) and twice by SPECT (SPECT I and SPECT II, n=15) on the same day. The MRI contrast agent was injected during MRI I but not MRI II to test the effect of imaging time after contrast. Resting Tc-MIBI SPECT images were acquired and infarct size was determined with commercial software. Infarct size in patients scanned by MRI and SPECT was 14±6% of left ventricular mass (%LV) by MRI (range 4%LV to 27%LV) and 14±7%LV by SPECT (range 4%LV to 26%LV). MRI I and II scans were performed 10±2 and 27±3 minutes after contrast, respectively. For MRI, the difference in infarct size between scans I and II (bias) was -0.1%LV, and the coefficient of repeatability was ±2.4%LV. For SPECT, bias was -1.3%LV, and the coefficient of repeatability was ±4.0%LV. Within individual patients, no systematic differences in infarct size were detected when the 2 MRI scans were compared, the 2 SPECT scans were compared, or MRI was compared to SPECT. Conclusion - The size of healed infarcts measured by contrast-enhanced MRI does not change between 10 and 30 minutes after contrast. The clinical reproducibility of contrast-enhanced MRI for infarct size determination compares favorably with that of routine clinical SPECT.

Original languageEnglish (US)
Pages (from-to)2322-2327
Number of pages6
Issue number18
StatePublished - Oct 29 2002
Externally publishedYes


  • Contrast media
  • Magnetic resonance imaging
  • Reproducibility
  • Scintigraphy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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