Reproducibility of biopsy diagnoses of endometrial hyperplasia: Evidence supporting a simplified classification

Mark E. Sherman, Brigitte M. Ronnett, Olga B. Ioffe, Douglas A. Richesson, Brenda B. Rush, Andrew G. Glass, Nilanjan Chatterjee, Maire A. Duggan, James V. Lacey

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


BACKGROUND: Identifying which categories in the World Health Organization classification of endometrial hyperplasia contribute to suboptimal reproducibility is clinically important. METHODS: A 2-member panel reviewed 209 endometrial biopsy/curettage specimens originally diagnosed as incident endometrial hyperplasia as part of a progression study. Original diagnoses included the following: disordered proliferative endometrium, simple hyperplasia, complex hyperplasia, and atypical hyperplasia; panel diagnoses also included negative and carcinoma. We assessed percentage agreement and kappa statistics±standard errors (K±SE). RESULTS: Original and panel diagnoses (combining negative with disordered proliferative endometrium; atypical hyperplasia with carcinoma) agreed for 34.9% of biopsies (K-unweighted±SE=0.18±0.03; K-weighted±SE=0.27±0.04) . Panelists' diagnoses agreed (using 6 categories) for 51.7% of biopsies, corresponding to K-unweighted±SE=0.37±0.03, improving with weighting to K-weighted±SE=0.63±0.05. Reproducibility based on a 2-tier classification ([negative, disordered proliferative endometrium, simple hyperplasia, or complex hyperplasia] versus [atypical hyperplasia or carcinoma]) increased agreement between original and panel diagnoses to 82.8%, K-unweighted±SE=0.37±0.06, and between panelists to 87.0%, K-unweighted±SE=0.63±0.07. Agreement between panelists at a cutpoint of complex hyperplasia and more severe versus simple hyperplasia or less severe was 88.0%, K-unweighted±SE=0.72±0.07. CONCLUSIONS: Developing and prospectively testing a binary system of classifying endometrial hyperplasia on endometrial biopsy may aid efforts to improve interobserver reproducibility.

Original languageEnglish (US)
Pages (from-to)318-325
Number of pages8
JournalInternational Journal of Gynecological Pathology
Issue number3
StatePublished - Jul 1 2008


  • Diagnosis
  • Endometrium
  • Hyperplasia
  • Reproducibility
  • WHO

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology


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