Representation of internal models of action in the autistic brain

Courtney C. Haswell; Jun Izawa; Lauren R Dowell; Stewart H Mostofsky; Reza Shadmehr

doi:10.1038/nn.2356

Representation of internal models of action in the autistic brain

Courtney C. Haswell, Jun Izawa, Lauren R Dowell, Stewart H Mostofsky, Reza Shadmehr

Research output: Contribution to journal › Article › peer-review

193 Scopus citations

Abstract

Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.

Original language	English (US)
Pages (from-to)	970-972
Number of pages	3
Journal	Nature neuroscience
Volume	12
Issue number	8
DOIs	https://doi.org/10.1038/nn.2356
State	Published - Aug 2009

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.",

author = "Haswell, {Courtney C.} and Jun Izawa and {R Dowell}, Lauren and {H Mostofsky}, Stewart and Reza Shadmehr",

note = "Funding Information: This research was funded by grants from the National Alliance for Autism Research/Autism Speaks, the US National Institutes of Health (R01 NS037422, R01 NS048527 and K02 NS044850) and the Johns Hopkins University School of Medicine Institute for Clinical and Translational Research, a US National Institutes of Health/National Center for Research Resources Clinical and Transitional Science Award Program (UL1-RR025005).",

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Representation of internal models of action in the autistic brain

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