TY - JOUR
T1 - Representation matters
T2 - a call for inclusivity and equity in heart failure clinical trials
AU - Reza, Nosheen
AU - Nayak, Aditi
AU - Lewsey, Sabra C.
AU - DeFilippis, Ersilia M.
N1 - Publisher Copyright:
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - The burden of heart failure remains substantial worldwide, and heart failure with reduced ejection fraction (HFrEF) affects approximately half of this population. Despite this global prevalence of HFrEF, the majority of contemporary clinical trials in HFrEF have underenrolled individuals from minoritized sex, gender, race, ethnicity, and socioeconomic groups. Moreover, significant disparities in access to HFrEF treatment and outcomes exist across these same strata. We provide a call to action for the inclusion of diverse populations in HFrEF clinical trials; catalogue several barriers to adequate representation in HFrEF clinical trials; and propose strategies to broaden inclusivity in future HFrEF trials.
AB - The burden of heart failure remains substantial worldwide, and heart failure with reduced ejection fraction (HFrEF) affects approximately half of this population. Despite this global prevalence of HFrEF, the majority of contemporary clinical trials in HFrEF have underenrolled individuals from minoritized sex, gender, race, ethnicity, and socioeconomic groups. Moreover, significant disparities in access to HFrEF treatment and outcomes exist across these same strata. We provide a call to action for the inclusion of diverse populations in HFrEF clinical trials; catalogue several barriers to adequate representation in HFrEF clinical trials; and propose strategies to broaden inclusivity in future HFrEF trials.
KW - Clinical trials
KW - Diversity
KW - Health equity
KW - Heart failure
UR - http://www.scopus.com/inward/record.url?scp=85154593415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85154593415&partnerID=8YFLogxK
U2 - 10.1093/eurheartjsupp/suac115
DO - 10.1093/eurheartjsupp/suac115
M3 - Article
C2 - 36545232
AN - SCOPUS:85154593415
SN - 1520-765X
VL - 24
SP - L45-L48
JO - European Heart Journal, Supplement
JF - European Heart Journal, Supplement
IS - Sl
ER -