Abstract
Aims: Increased T peaks cloud volume is associated with increased risk of ventricular arrhythmias (VA) in cardiomyopathy (CM) patients. T peaks cloud volume is formed, as a result, of (1) the angle between consecutive T-vectors and (2) temporal variability in T-vector amplitude. This study compares association of these two factors with VA. Methods: Baseline orthogonal ECGs were recorded during 5 min at rest in 414 patients with structural heart disease [mean age 59.4±12.0; 68% whites; 73% men; 45% non-ischemic CM] before implantation of implantable cardioverter-defibrillator (ICD) for primary prevention of sudden cardiac death. The spatial TT' angle between consecutive spatial T vectors was calculated using the definition of the inner product. Results: During a median 14 months of follow-up, 61 patients experienced sustained VA with appropriate ICD therapies. In a multivariable Cox regression model after adjustment for age, sex, race, spatial TT' angle was associated with VA (HR 1.03; 95%CI 1.0-1.05; P=0.034). Interaction with CM type was found: TT' angle was strongly associated with polymorphic VT/VF in non-ischemic CM (HR 1.04; 95%CI 1.0-1.05; P=0.033). Conclusion: Increased spatial TT' angle is associated with increased risk of VA.
Original language | English (US) |
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Title of host publication | Computing in Cardiology |
Publisher | IEEE Computer Society |
Pages | 181-184 |
Number of pages | 4 |
Volume | 41 |
Edition | January |
State | Published - 2014 |
Event | 41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States Duration: Sep 7 2014 → Sep 10 2014 |
Other
Other | 41st Computing in Cardiology Conference, CinC 2014 |
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Country/Territory | United States |
City | Cambridge |
Period | 9/7/14 → 9/10/14 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Computer Science(all)