TY - JOUR
T1 - Replication Study Confirms Link between TSPAN18 Mutation and Schizophrenia in Han Chinese
AU - Yuan, Jianmin
AU - Jin, Chunhui
AU - Qin, Hai De
AU - Wang, Jidong
AU - Sha, Weiwei
AU - Wang, Mingzhong
AU - Zhang, Yunbiao
AU - Zhang, Fuquan
AU - Li, Jijiang
AU - Li, Jianfeng
AU - Yu, Shui
AU - Qi, Shuguang
AU - Shugart, Yin Yao
PY - 2013/3/7
Y1 - 2013/3/7
N2 - Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784) in the tetraspanins gene TSPAN18 as possible susceptibility loci for schizophrenia. Hoping to validate these findings, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls. Using the LDR-PCR method to genotype polymorphisms in TSPAN18, we found no significant differences (P>0.05) between patients and controls in either the allele or genotype frequency of the SNPs rs11038167 and rs11038172. We did find, however, that the frequency of the 'A' allele of SNP rs835784 is significantly higher in patients than in controls. We further observed a significant association (OR = 1.197, 95%CI = 1.047-1.369) between risk for SCZ and this 'A' allele. These results confirm the significant association, in Han Chinese populations, of increased SCZ risk and the variant of the TSPAN18 gene containing the 'A' allele of SNP rs835784.
AB - Schizophrenia (SCZ) is a severe psychiatric disorder associated with many different risk factors, both genetic and environmental. A recent genome-wide association study (GWAS) of Han Chinese identified three single-nucleotide polymorphisms (SNPs rs11038167, rs11038172, and rs835784) in the tetraspanins gene TSPAN18 as possible susceptibility loci for schizophrenia. Hoping to validate these findings, we conducted a case-control study of Han Chinese with 1093 schizophrenia cases and 1022 healthy controls. Using the LDR-PCR method to genotype polymorphisms in TSPAN18, we found no significant differences (P>0.05) between patients and controls in either the allele or genotype frequency of the SNPs rs11038167 and rs11038172. We did find, however, that the frequency of the 'A' allele of SNP rs835784 is significantly higher in patients than in controls. We further observed a significant association (OR = 1.197, 95%CI = 1.047-1.369) between risk for SCZ and this 'A' allele. These results confirm the significant association, in Han Chinese populations, of increased SCZ risk and the variant of the TSPAN18 gene containing the 'A' allele of SNP rs835784.
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U2 - 10.1371/journal.pone.0058785
DO - 10.1371/journal.pone.0058785
M3 - Article
C2 - 23505562
AN - SCOPUS:84874738644
SN - 1932-6203
VL - 8
JO - PLoS One
JF - PLoS One
IS - 3
M1 - e58785
ER -