Replication of kinetoplast DNA: An update for the new millennium

James C. Morris; Mark E. Drew; Michele M. Klingbeil; Shawn A. Motyka; Tina T. Saxowsky; Zefeng Wang; Paul T. Englund

doi:10.1016/S0020-7519(01)00156-4

Replication of kinetoplast DNA: An update for the new millennium

James C. Morris, Mark E. Drew, Michele M. Klingbeil, Shawn A. Motyka, Tina T. Saxowsky, Zefeng Wang, Paul T. Englund

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

In this review we will describe the replication of kinetoplast DNA, a subject that our lab has studied for many years. Our knowledge of kinetoplast DNA replication has depended mostly upon the investigation of the biochemical properties and intramitochondrial localisation of replication proteins and enzymes as well as a study of the structure and dynamics of kinetoplast DNA replication intermediates. We will first review the properties of the characterised kinetoplast DNA replication proteins and then describe our current model for kinetoplast DNA replication.

Original language	English (US)
Pages (from-to)	453-458
Number of pages	6
Journal	International Journal for Parasitology
Volume	31
Issue number	5-6
DOIs	https://doi.org/10.1016/S0020-7519(01)00156-4
State	Published - May 1 2001
Externally published	Yes

Keywords

DNA replication
Kinetoplast DNA
Trypanosoma

ASJC Scopus subject areas

Parasitology
Infectious Diseases

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10.1016/S0020-7519(01)00156-4

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title = "Replication of kinetoplast DNA: An update for the new millennium",

abstract = "In this review we will describe the replication of kinetoplast DNA, a subject that our lab has studied for many years. Our knowledge of kinetoplast DNA replication has depended mostly upon the investigation of the biochemical properties and intramitochondrial localisation of replication proteins and enzymes as well as a study of the structure and dynamics of kinetoplast DNA replication intermediates. We will first review the properties of the characterised kinetoplast DNA replication proteins and then describe our current model for kinetoplast DNA replication.",

keywords = "DNA replication, Kinetoplast DNA, Trypanosoma",

author = "Morris, {James C.} and Drew, {Mark E.} and Klingbeil, {Michele M.} and Motyka, {Shawn A.} and Saxowsky, {Tina T.} and Zefeng Wang and Englund, {Paul T.}",

note = "Funding Information: We thank Viiu Klein for valuable contributions to this work. M.M.K. is supported by National Research Service Award Fellowship 5F32AI09789. T.T.S. is supported by the Fannie and John Hertz Foundation. Work in our lab is supported by grant GM 27608 from the National Institutes of Health.",

year = "2001",

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doi = "10.1016/S0020-7519(01)00156-4",

language = "English (US)",

volume = "31",

pages = "453--458",

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T2 - An update for the new millennium

AU - Morris, James C.

AU - Drew, Mark E.

AU - Klingbeil, Michele M.

AU - Motyka, Shawn A.

AU - Saxowsky, Tina T.

AU - Wang, Zefeng

AU - Englund, Paul T.

N1 - Funding Information: We thank Viiu Klein for valuable contributions to this work. M.M.K. is supported by National Research Service Award Fellowship 5F32AI09789. T.T.S. is supported by the Fannie and John Hertz Foundation. Work in our lab is supported by grant GM 27608 from the National Institutes of Health.

PY - 2001/5/1

Y1 - 2001/5/1

N2 - In this review we will describe the replication of kinetoplast DNA, a subject that our lab has studied for many years. Our knowledge of kinetoplast DNA replication has depended mostly upon the investigation of the biochemical properties and intramitochondrial localisation of replication proteins and enzymes as well as a study of the structure and dynamics of kinetoplast DNA replication intermediates. We will first review the properties of the characterised kinetoplast DNA replication proteins and then describe our current model for kinetoplast DNA replication.

AB - In this review we will describe the replication of kinetoplast DNA, a subject that our lab has studied for many years. Our knowledge of kinetoplast DNA replication has depended mostly upon the investigation of the biochemical properties and intramitochondrial localisation of replication proteins and enzymes as well as a study of the structure and dynamics of kinetoplast DNA replication intermediates. We will first review the properties of the characterised kinetoplast DNA replication proteins and then describe our current model for kinetoplast DNA replication.

KW - DNA replication

KW - Kinetoplast DNA

KW - Trypanosoma

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Replication of kinetoplast DNA: An update for the new millennium

Abstract

Keywords

ASJC Scopus subject areas

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