Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand

Bruce Y. Lee, Tina Marie Assi, Korngamon Rookkapan, Diana L. Connor, Jayant Rajgopal, Vorasith Sornsrivichai, Shawn T. Brown, Joel S. Welling, Bryan A. Norman, Sheng I. Chen, Rachel R. Bailey, Ann E. Wiringa, Angela R. Wateska, Anirban Jana, Willem G. Van Panhuis, Donald S Burke

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Introduced to minimize open vial wastage, single-dose vaccine vials require more storage space and therefore may affect vaccine supply chains (i.e., the series of steps and processes involved in distributing vaccines from manufacturers to patients). We developed a computational model of Thailand's Trang province vaccine supply chain to analyze the effects of switching from a ten-dose measles vaccine presentation to each of the following: a single-dose measles-mumps-rubella vaccine (which Thailand is currently considering) or a single-dose measles vaccine. While the Trang province vaccine supply chain would generally have enough storage and transport capacity to accommodate the switches, the added volume could push some locations' storage and transport space utilization close to their limits. Single-dose vaccines would allow for more precise ordering and decrease open vial waste, but decrease reserves for unanticipated demand. Moreover, the added disposal and administration costs could far outweigh the costs saved from preventing open vial wastage.

Original languageEnglish (US)
Pages (from-to)3811-3817
Number of pages7
Issue number21
StatePublished - May 12 2011
Externally publishedYes


  • Measles vaccine
  • Single-dose
  • Vaccine supply chain

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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