Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand

Bruce Y. Lee; Tina Marie Assi; Korngamon Rookkapan; Diana L. Connor; Jayant Rajgopal; Vorasith Sornsrivichai; Shawn T. Brown; Joel S. Welling; Bryan A. Norman; Sheng I. Chen; Rachel R. Bailey; Ann E. Wiringa; Angela R. Wateska; Anirban Jana; Willem G. Van Panhuis; Donald S Burke

doi:10.1016/j.vaccine.2011.03.013

Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand

Bruce Y. Lee, Tina Marie Assi, Korngamon Rookkapan, Diana L. Connor, Jayant Rajgopal, Vorasith Sornsrivichai, Shawn T. Brown, Joel S. Welling, Bryan A. Norman, Sheng I. Chen, Rachel R. Bailey, Ann E. Wiringa, Angela R. Wateska, Anirban Jana, Willem G. Van Panhuis, Donald S Burke

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Introduced to minimize open vial wastage, single-dose vaccine vials require more storage space and therefore may affect vaccine supply chains (i.e., the series of steps and processes involved in distributing vaccines from manufacturers to patients). We developed a computational model of Thailand's Trang province vaccine supply chain to analyze the effects of switching from a ten-dose measles vaccine presentation to each of the following: a single-dose measles-mumps-rubella vaccine (which Thailand is currently considering) or a single-dose measles vaccine. While the Trang province vaccine supply chain would generally have enough storage and transport capacity to accommodate the switches, the added volume could push some locations' storage and transport space utilization close to their limits. Single-dose vaccines would allow for more precise ordering and decrease open vial waste, but decrease reserves for unanticipated demand. Moreover, the added disposal and administration costs could far outweigh the costs saved from preventing open vial wastage.

Original language	English (US)
Pages (from-to)	3811-3817
Number of pages	7
Journal	Vaccine
Volume	29
Issue number	21
DOIs	https://doi.org/10.1016/j.vaccine.2011.03.013
State	Published - May 12 2011
Externally published	Yes

Keywords

Measles vaccine
Single-dose
Vaccine supply chain

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2011.03.013

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Lee, B. Y., Assi, T. M., Rookkapan, K., Connor, D. L., Rajgopal, J., Sornsrivichai, V., Brown, S. T., Welling, J. S., Norman, B. A., Chen, S. I., Bailey, R. R., Wiringa, A. E., Wateska, A. R., Jana, A., Van Panhuis, W. G., & Burke, D. S. (2011). Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand. Vaccine, 29(21), 3811-3817. https://doi.org/10.1016/j.vaccine.2011.03.013

Lee, BY, Assi, TM, Rookkapan, K, Connor, DL, Rajgopal, J, Sornsrivichai, V, Brown, ST, Welling, JS, Norman, BA, Chen, SI, Bailey, RR, Wiringa, AE, Wateska, AR, Jana, A, Van Panhuis, WG & Burke, DS 2011, 'Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand', Vaccine, vol. 29, no. 21, pp. 3811-3817. https://doi.org/10.1016/j.vaccine.2011.03.013

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abstract = "Introduced to minimize open vial wastage, single-dose vaccine vials require more storage space and therefore may affect vaccine supply chains (i.e., the series of steps and processes involved in distributing vaccines from manufacturers to patients). We developed a computational model of Thailand's Trang province vaccine supply chain to analyze the effects of switching from a ten-dose measles vaccine presentation to each of the following: a single-dose measles-mumps-rubella vaccine (which Thailand is currently considering) or a single-dose measles vaccine. While the Trang province vaccine supply chain would generally have enough storage and transport capacity to accommodate the switches, the added volume could push some locations' storage and transport space utilization close to their limits. Single-dose vaccines would allow for more precise ordering and decrease open vial waste, but decrease reserves for unanticipated demand. Moreover, the added disposal and administration costs could far outweigh the costs saved from preventing open vial wastage.",

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note = "Funding Information: This study was supported by the Vaccine Modeling Initiative (VMI), funded by the Bill and Melinda Gates Foundation and the National Institute of General Medical Sciences Models of Infectious Disease Agent Study (MIDAS) grant 1U54GM088491-0109 . The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. ",

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N2 - Introduced to minimize open vial wastage, single-dose vaccine vials require more storage space and therefore may affect vaccine supply chains (i.e., the series of steps and processes involved in distributing vaccines from manufacturers to patients). We developed a computational model of Thailand's Trang province vaccine supply chain to analyze the effects of switching from a ten-dose measles vaccine presentation to each of the following: a single-dose measles-mumps-rubella vaccine (which Thailand is currently considering) or a single-dose measles vaccine. While the Trang province vaccine supply chain would generally have enough storage and transport capacity to accommodate the switches, the added volume could push some locations' storage and transport space utilization close to their limits. Single-dose vaccines would allow for more precise ordering and decrease open vial waste, but decrease reserves for unanticipated demand. Moreover, the added disposal and administration costs could far outweigh the costs saved from preventing open vial wastage.

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Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand

Abstract

Keywords

ASJC Scopus subject areas

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