Repetitive and Self-injurious Behaviors in Children with Cornelia de Lange Syndrome

Siddharth Srivastava, Bennett Clark, Colleen Landy-Schmitt, Elizabeth A. Offermann, Antonie D. Kline, Samuel T. Wilkinson, Marco A. Grados

Research output: Contribution to journalArticlepeer-review


Cornelia de Lange syndrome (CdLS) is associated with repetitive and self-injurious behaviors (RBs, SIB). Evaluating children with CdLS, this study: (1) characterizes the spectrum of RBs; (2) characterizes the impact and severity of RBs including SIB; (3) describes how age and adaptive functioning relate to RBs including SIB. Fifty children (5–17 years) with CdLS were assessed with Children’s Yale-Brown Obsessive Compulsive Scale Modified for PDD; Aberrant Behavior Checklist (ABC); Vineland Adaptive Behaviors Scales (VABS). All children had ≥ 1 type of RB; 44% had some form of SIB. 64% spent > 1 h/day displaying RBs. Lower VABS adaptive functioning was associated with higher stereotypy and SIB scores (ABC). In children with CdLS, RBs including SIB are common, impactful, and associated with lower adaptive functioning.

Original languageEnglish (US)
Pages (from-to)1748-1758
Number of pages11
JournalJournal of Autism and Developmental Disorders
Issue number5
StatePublished - May 2021


  • Cornelia de Lange syndrome
  • Repetitive behaviors
  • Self-injurious behaviors
  • Stereotypies

ASJC Scopus subject areas

  • Developmental and Educational Psychology


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