Repeatability and robustness of MP-GRASP T1 mapping

Zhitao Li, Xiang Xu, Yang Yang, Li Feng

Research output: Contribution to journalArticlepeer-review


Purpose: To demonstrate the repeatability of fast 3D T1 mapping using Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI and its robustness to variation of imaging parameters including flip angle and spatial resolution in phantoms and the brain. Theory and Methods: Multiple imaging experiments were performed to (1) assess the robustness of MP-GRASP T1 mapping to B1 inhomogeneity using a single tube phantom filled with uniform MnCl2 liquid; (2) compare the repeatability of T1 mapping between MP-GRASP and inversion recovery-based spin-echo (IR-SE; over 12 scans), using a commercial T1MES phantom; (3) evaluate the longitudinal variation of T1 estimation using MP-GRASP with varying imaging parameters, including spatial resolution, flip angle, TR/TE, and acceleration rate, using the T1MES phantom (106 scans performed over a period of 12 months); and (4) evaluate the variation of T1 estimation using MP-GRASP with varying imaging parameters in the brain (24 scans in a single visit). In addition, the accuracy of MP-GRASP T1 mapping was also validated against IR-SE by performing linear correlation and calculating the Lin's concordance correlation coefficient (CCC). Results: MP-GRASP demonstrates good robustness to B1 inhomogeneity, with intra-slice variability below 1% in the single tube phantom experiment. The longitudinal variability is good both in the phantom (below 2.5%) and in the brain (below 2%) with varying imaging parameters. The T1 values estimated from MP-GRASP are accurate compared to that from the IR-SE imaging (R2 = 0.997, Lin’s CCC = 0.996). Conclusion: MP-GRASP shows excellent repeatability of T1 estimation over time, and it is also robust to variation of different imaging parameters evaluated in this study.

Original languageEnglish (US)
Pages (from-to)2271-2286
Number of pages16
JournalMagnetic resonance in medicine
Issue number5
StatePublished - May 2022


  • Golden-angle
  • Look-Locker
  • T mapping
  • repeatability

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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