Repair of peripheral nerves of unequal diameters

Daniel K. Hinckley, C. Alan Lyles, Douglas E. Mattox

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Four techniques for anastomosis were investigated for the anastomosis of a large proximal segment to a smaller distal segment of rat peripheral nerve with a size disparity of approximately 3 to 1. The techniques were perineural sutures (group I), KTP laser annealing (group II), collagen tubes with a 5-mm gap between the nerve segments (group III), and collagen tubes without a gap between the nerve ends (group IV).At 6 weeks there were no gross nerve distractions in groups I or IV. There were two failures in group II and three in group III. The percentage of fibers that crossed intact anastomoses were: group I, 89%; group II, 75%; group III, 115%; group IV, 125% (P<.05 for the collagen tube repairs).Our results indicate that the suture technique is still the most reliable method of nerve repair. However, collagen tubes were effective in increasing the percentage of axons crossing the anastomosis.

Original languageEnglish (US)
Pages (from-to)1150-1154
Number of pages5
Issue number11
StatePublished - Nov 1991
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology


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