TY - JOUR
T1 - Renal dysfunction in children with uncomplicated, Plasmodium falciparum malaria in Tamale, Ghana
AU - Burchard, G. D.
AU - Ehrhardt, S.
AU - Mockenhaupt, F. P.
AU - Mathieu, A.
AU - Agana-Nsiire, P.
AU - Anemana, S. D.
AU - Otchwemah, R. N.
AU - Abel, W.
AU - Brattig, N.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - In a study performed in Tamale, in the Northern region of Ghana, cystatin C, a new and sensitive indicator of the glomerular filtration rate (GFR), was used to estimate the frequency of renal dysfunction in 78 children with uncomplicated, Plasmodium falciparum malaria. The excretion in urine of albumin, immunoglobulin G and α1-microglobulin was also investigated. Plasma concentrations of cystatin C were found to be elevated in 17% of the children, indicating subclinical impairment of renal function. As most (85%) of the children had glomerular as well as tubular patterns of proteinuria, it appears that both glomerulonephritis and damage to tubular cells often occur in P. falciparum malaria.
AB - In a study performed in Tamale, in the Northern region of Ghana, cystatin C, a new and sensitive indicator of the glomerular filtration rate (GFR), was used to estimate the frequency of renal dysfunction in 78 children with uncomplicated, Plasmodium falciparum malaria. The excretion in urine of albumin, immunoglobulin G and α1-microglobulin was also investigated. Plasma concentrations of cystatin C were found to be elevated in 17% of the children, indicating subclinical impairment of renal function. As most (85%) of the children had glomerular as well as tubular patterns of proteinuria, it appears that both glomerulonephritis and damage to tubular cells often occur in P. falciparum malaria.
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U2 - 10.1179/000349803235002281
DO - 10.1179/000349803235002281
M3 - Article
C2 - 12831520
AN - SCOPUS:0037561414
SN - 2047-7724
VL - 97
SP - 345
EP - 350
JO - Pathogens and Global Health
JF - Pathogens and Global Health
IS - 4
ER -