TY - JOUR
T1 - Remote Monitoring of Visual Function in Patients with Maculopathy
T2 - The Aphelion Study
AU - Joseph, Anthony
AU - Bullimore, Mark
AU - Drawnel, Faye
AU - Miranda, Marco
AU - Morgan, Zoe
AU - Wang, Yi Zhong
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2024/1
Y1 - 2024/1
N2 - Introduction: Remote monitoring of vision, using tools such as the shape discrimination hyperacuity (SDH) test, can detect disease activity in patients with maculopathy. We determined the in-clinic accuracy and repeatability of three myVisionTrack expanded version (mVTx) tests for self-testing of visual acuity (VA) and contrast sensitivity. Methods: Aphelion, a single-arm, prospective study conducted at two sites in the USA, included adults with any maculopathy and a baseline VA of 0.7 log of minimum angle of resolution (logMAR) (Snellen 20/100) or better. Participants completed the mVTx tests (tumbling E, Landolt C, contrast sensitivity, and SDH) and standard clinical tests (near and distance Early Treatment Diabetic Retinopathy Study [ETDRS] charts and the Pelli–Robson contrast sensitivity chart). Test–retest repeatability and agreement between the mVTx tests and the corresponding clinical test were assessed by Bland–Altman analyses. Participants also completed a usability survey. Results: The mean age of the 122 participants was 67 years. The most common diagnosis was age-related macular degeneration (42% of patients). The tumbling E test had a test–retest 95% limit of agreement (LoA) of ± 0.18 logMAR; the Landolt C test, ± 0.23 logMAR; the SDH test, ± 0.24 logMAR; and the contrast sensitivity test, ± 0.32 log contrast threshold (logCT). Compared with the distance ETDRS chart, the LoA was ± 0.35 logMAR for the tumbling E test (mean difference, − 0.07 logMAR) and ± 0.39 logMAR for the Landolt C test (mean difference, 0.03 logMAR). For the contrast sensitivity test, the LoA compared with the Pelli–Robson chart was ± 0.30 logCT (mean difference, − 0.25 logCT). Most participants (85%) reported that they learned the tests quickly. The tumbling E test scored the highest on ease of use. Conclusion: The mVTx tests of VA are accurate and repeatable, supporting their potential use alongside the SDH test to detect disease progression remotely between clinic visits.
AB - Introduction: Remote monitoring of vision, using tools such as the shape discrimination hyperacuity (SDH) test, can detect disease activity in patients with maculopathy. We determined the in-clinic accuracy and repeatability of three myVisionTrack expanded version (mVTx) tests for self-testing of visual acuity (VA) and contrast sensitivity. Methods: Aphelion, a single-arm, prospective study conducted at two sites in the USA, included adults with any maculopathy and a baseline VA of 0.7 log of minimum angle of resolution (logMAR) (Snellen 20/100) or better. Participants completed the mVTx tests (tumbling E, Landolt C, contrast sensitivity, and SDH) and standard clinical tests (near and distance Early Treatment Diabetic Retinopathy Study [ETDRS] charts and the Pelli–Robson contrast sensitivity chart). Test–retest repeatability and agreement between the mVTx tests and the corresponding clinical test were assessed by Bland–Altman analyses. Participants also completed a usability survey. Results: The mean age of the 122 participants was 67 years. The most common diagnosis was age-related macular degeneration (42% of patients). The tumbling E test had a test–retest 95% limit of agreement (LoA) of ± 0.18 logMAR; the Landolt C test, ± 0.23 logMAR; the SDH test, ± 0.24 logMAR; and the contrast sensitivity test, ± 0.32 log contrast threshold (logCT). Compared with the distance ETDRS chart, the LoA was ± 0.35 logMAR for the tumbling E test (mean difference, − 0.07 logMAR) and ± 0.39 logMAR for the Landolt C test (mean difference, 0.03 logMAR). For the contrast sensitivity test, the LoA compared with the Pelli–Robson chart was ± 0.30 logCT (mean difference, − 0.25 logCT). Most participants (85%) reported that they learned the tests quickly. The tumbling E test scored the highest on ease of use. Conclusion: The mVTx tests of VA are accurate and repeatable, supporting their potential use alongside the SDH test to detect disease progression remotely between clinic visits.
KW - Contrast sensitivity
KW - Hyperacuity
KW - Maculopathy
KW - Remote monitoring
KW - Smartphone application
KW - Visual acuity
UR - http://www.scopus.com/inward/record.url?scp=85177748038&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85177748038&partnerID=8YFLogxK
U2 - 10.1007/s40123-023-00854-2
DO - 10.1007/s40123-023-00854-2
M3 - Article
C2 - 38015309
AN - SCOPUS:85177748038
SN - 2193-8245
VL - 13
SP - 409
EP - 422
JO - Ophthalmology and Therapy
JF - Ophthalmology and Therapy
IS - 1
ER -