TY - JOUR
T1 - Reliability of early cortical auditory gamma-band responses
AU - Cervenka, Mackenzie C.
AU - Franaszczuk, Piotr J.
AU - Crone, Nathan E.
AU - Hong, Bo
AU - Caffo, Brian S.
AU - Bhatt, Paras
AU - Lenz, Frederick A.
AU - Boatman-Reich, Dana
N1 - Funding Information:
This study was supported by NIH grants NIDCD DC005645 and DC010028 (D.B.R.); NIBIB EB012547 (B.C.); NINDS NS40596 (N.E.C.) and NS038493 (F.A.L.); and by the National Science Foundation of China Project 61071003 (B.H.). Special thanks to Dr. Deepti Ramadoss and Juan Roberto Perilla for assistance with the manuscript and figures.
PY - 2013/1
Y1 - 2013/1
N2 - Objective: To evaluate the test-retest reliability of event-related power changes in the 30-150. Hz gamma frequency range occurring in the first 150. ms after presentation of an auditory stimulus. Methods: Repeat intracranial electrocorticographic (ECoG) recordings were performed with 12 epilepsy patients, at ≥1-day intervals, using a passive odd-ball paradigm with steady-state tones. Time-frequency matching pursuit analysis was used to quantify changes in gamma-band power relative to pre-stimulus baseline. Test-retest reliability was estimated based on within-subject comparisons (paired t-test, McNemar's test) and correlations (Spearman rank correlations, intra-class correlations) across sessions, adjusting for within-session variability. Reliability estimates of gamma-band response robustness, spatial concordance, and reproducibility were compared with corresponding measurements from concurrent auditory evoked N1 responses. Results: All patients showed increases in gamma-band power, 50-120. ms post-stimulus onset, that were highly robust across recordings, comparable to the evoked N1 responses. Gamma-band responses occurred regardless of patients' performance on behavioral tests of auditory processing, medication changes, seizure focus, or duration of test-retest interval. Test-retest reproducibility was greatest for the timing of peak power changes in the high-gamma range (65-150. Hz). Reliability of low-gamma responses and evoked N1 responses improved at higher signal-to-noise levels. Conclusions: Early cortical auditory gamma-band responses are robust, spatially concordant, and reproducible over time. Significance: These test-retest ECoG results confirm the reliability of auditory gamma-band responses, supporting their utility as objective measures of cortical processing in clinical and research studies.
AB - Objective: To evaluate the test-retest reliability of event-related power changes in the 30-150. Hz gamma frequency range occurring in the first 150. ms after presentation of an auditory stimulus. Methods: Repeat intracranial electrocorticographic (ECoG) recordings were performed with 12 epilepsy patients, at ≥1-day intervals, using a passive odd-ball paradigm with steady-state tones. Time-frequency matching pursuit analysis was used to quantify changes in gamma-band power relative to pre-stimulus baseline. Test-retest reliability was estimated based on within-subject comparisons (paired t-test, McNemar's test) and correlations (Spearman rank correlations, intra-class correlations) across sessions, adjusting for within-session variability. Reliability estimates of gamma-band response robustness, spatial concordance, and reproducibility were compared with corresponding measurements from concurrent auditory evoked N1 responses. Results: All patients showed increases in gamma-band power, 50-120. ms post-stimulus onset, that were highly robust across recordings, comparable to the evoked N1 responses. Gamma-band responses occurred regardless of patients' performance on behavioral tests of auditory processing, medication changes, seizure focus, or duration of test-retest interval. Test-retest reproducibility was greatest for the timing of peak power changes in the high-gamma range (65-150. Hz). Reliability of low-gamma responses and evoked N1 responses improved at higher signal-to-noise levels. Conclusions: Early cortical auditory gamma-band responses are robust, spatially concordant, and reproducible over time. Significance: These test-retest ECoG results confirm the reliability of auditory gamma-band responses, supporting their utility as objective measures of cortical processing in clinical and research studies.
KW - Auditory cortex
KW - Auditory processing
KW - Gamma-band
KW - Reliability
KW - Variability
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U2 - 10.1016/j.clinph.2012.06.003
DO - 10.1016/j.clinph.2012.06.003
M3 - Article
C2 - 22771035
AN - SCOPUS:84871443618
SN - 1388-2457
VL - 124
SP - 70
EP - 82
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 1
ER -