TY - JOUR
T1 - Relationship of Hepatocellular Carcinoma Stage and Hepatic Function to Health-Related Quality of Life
T2 - A Single Center Analysis
AU - Gupta, Amol
AU - Zorzi, Jane
AU - Ho, Won Jin
AU - Baretti, Marina
AU - Azad, Nilofer Saba
AU - Griffith, Paige
AU - Dao, Doan
AU - Kim, Amy
AU - Philosophe, Benjamin
AU - Georgiades, Christos
AU - Kamel, Ihab
AU - Burkhart, Richard
AU - Liddell, Robert
AU - Hong, Kelvin
AU - Shubert, Christopher
AU - Lafaro, Kelly
AU - Meyer, Jeffrey
AU - Anders, Robert
AU - Burns, William
AU - Yarchoan, Mark
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/9
Y1 - 2023/9
N2 - Health-related quality of life (HRQoL) is known to be an important prognostic indicator and clinical endpoint for patients with hepatocellular carcinoma (HCC). However, the correlation of the Barcelona Clinic Liver Cancer (BCLC) stage with HRQoL in HCC has not been previously studied. We examined the relationship between BCLC stage, Child–Pugh (CP) score, and Eastern Cooperative Oncology Group (ECOG) performance status on HRQoL for patients who presented at a multidisciplinary liver cancer clinic. HRQoL was assessed using the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire. Fifty-one patients met our inclusion criteria. The FACT-Hep total and subscales showed no significant association with BCLC stages (p = 0.224). Patients with CP B had significantly more impairment in FACT-Hep than patients with CP A. These data indicate that in patients with HCC, impaired liver function is associated with reduced quality of life, whereas the BCLC stage poorly correlates with quality of life metrics. Impairment of quality of life is common in HCC patients and further studies are warranted to determine the impact of early supportive interventions on HRQoL and survival outcomes.
AB - Health-related quality of life (HRQoL) is known to be an important prognostic indicator and clinical endpoint for patients with hepatocellular carcinoma (HCC). However, the correlation of the Barcelona Clinic Liver Cancer (BCLC) stage with HRQoL in HCC has not been previously studied. We examined the relationship between BCLC stage, Child–Pugh (CP) score, and Eastern Cooperative Oncology Group (ECOG) performance status on HRQoL for patients who presented at a multidisciplinary liver cancer clinic. HRQoL was assessed using the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire. Fifty-one patients met our inclusion criteria. The FACT-Hep total and subscales showed no significant association with BCLC stages (p = 0.224). Patients with CP B had significantly more impairment in FACT-Hep than patients with CP A. These data indicate that in patients with HCC, impaired liver function is associated with reduced quality of life, whereas the BCLC stage poorly correlates with quality of life metrics. Impairment of quality of life is common in HCC patients and further studies are warranted to determine the impact of early supportive interventions on HRQoL and survival outcomes.
KW - Child–Pugh score
KW - health-related quality of life
KW - hepatocellular carcinoma
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U2 - 10.3390/healthcare11182571
DO - 10.3390/healthcare11182571
M3 - Article
C2 - 37761768
AN - SCOPUS:85172195589
SN - 2227-9032
VL - 11
JO - Healthcare (Switzerland)
JF - Healthcare (Switzerland)
IS - 18
M1 - 2571
ER -