Relationship of Hepatitis B Virus Infection to Human Immunodeficiency Virus Type 1 Infection

Shiing Jer Twu; Roger Detels; Kenrad Nelson; Barbara R. Visscher; Richard Kaslow; John Palenicek; John Phair

doi:10.1093/infdis/167.2.299

Relationship of Hepatitis B Virus Infection to Human Immunodeficiency Virus Type 1 Infection

Shiing Jer Twu, Roger Detels, Kenrad Nelson, Barbara R. Visscher, Richard Kaslow, John Palenicek, John Phair

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The Multicenter AIDS Cohort Study (MACS) was designed to study the natural history of human immunodeficiency virus type 1 (HIV-1) infection, including the relationship between hepatitis B virus (HBV) and HIV-1 infection. In total, 4954 homosexual men were recruited from April 1984 through March 1985 and have been followed up thereafter every 6 months. Hepatitis B surface antigen and hepatitis B core antibody were tested for at the first visit by RIA or EIA; HIV-1 antibody testing was done at each visit by ELISA and confirmed by Western blot assay. The role of HBV infection in HIV-1 seroconversion was studied by stratification for sexual behavior and disease visit by visit. The adjusted risk ratio was 2.02 for hepatitis Bsurface antigen carriers and 2.14 for hepatitis-immune cases compared with hepatitis B-susceptible subjects. Similar results were obtained using a logistic regression model. After taking into account changes in sexual behavior and disease over time, the authors conclude that past HBV infection remains suspect as a cofactor or as a surrogate for other factors associated with HIV-1 seroconversion.

Original language	English (US)
Pages (from-to)	299-304
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	167
Issue number	2
DOIs	https://doi.org/10.1093/infdis/167.2.299
State	Published - Feb 1993
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1093/infdis/167.2.299

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@article{712861c53ee5441ebadc60a12f4c5855,

title = "Relationship of Hepatitis B Virus Infection to Human Immunodeficiency Virus Type 1 Infection",

abstract = "The Multicenter AIDS Cohort Study (MACS) was designed to study the natural history of human immunodeficiency virus type 1 (HIV-1) infection, including the relationship between hepatitis B virus (HBV) and HIV-1 infection. In total, 4954 homosexual men were recruited from April 1984 through March 1985 and have been followed up thereafter every 6 months. Hepatitis B surface antigen and hepatitis B core antibody were tested for at the first visit by RIA or EIA; HIV-1 antibody testing was done at each visit by ELISA and confirmed by Western blot assay. The role of HBV infection in HIV-1 seroconversion was studied by stratification for sexual behavior and disease visit by visit. The adjusted risk ratio was 2.02 for hepatitis Bsurface antigen carriers and 2.14 for hepatitis-immune cases compared with hepatitis B-susceptible subjects. Similar results were obtained using a logistic regression model. After taking into account changes in sexual behavior and disease over time, the authors conclude that past HBV infection remains suspect as a cofactor or as a surrogate for other factors associated with HIV-1 seroconversion.",

author = "Twu, {Shiing Jer} and Roger Detels and Kenrad Nelson and Visscher, {Barbara R.} and Richard Kaslow and John Palenicek and John Phair",

note = "Funding Information: Received 16 March 1992; revised 28 September 1992. Presented in part: VII International Conference on AIDS, Florence, Italy, June 1991, (abstract M.C.3191). Informed consent was obtained from participants, and guidelines for human experimentation ofthe US Department of Health and Human Services and the Human Subject Protection Committee of the University ofCalifornia, Los Angeles were followed in the conduct of the clinical research. Grant support: National Institutes of Health (AI-7263I , -72634, -72676, -32535, and -72632). Reprints or correspondence: Dr. Roger Detels, Dept. of Epidemiology, UCLA School of Public Health, 10833 Le Conte Ave., Los Angeles, CA 90024-1772. * Present affiliation: Institute of Public Health, Medical College, National Taiwan University, Taipei, Taiwan, Republic ofChina.",

year = "1993",

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doi = "10.1093/infdis/167.2.299",

language = "English (US)",

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T1 - Relationship of Hepatitis B Virus Infection to Human Immunodeficiency Virus Type 1 Infection

AU - Twu, Shiing Jer

AU - Detels, Roger

AU - Nelson, Kenrad

AU - Visscher, Barbara R.

AU - Kaslow, Richard

AU - Palenicek, John

AU - Phair, John

N1 - Funding Information: Received 16 March 1992; revised 28 September 1992. Presented in part: VII International Conference on AIDS, Florence, Italy, June 1991, (abstract M.C.3191). Informed consent was obtained from participants, and guidelines for human experimentation ofthe US Department of Health and Human Services and the Human Subject Protection Committee of the University ofCalifornia, Los Angeles were followed in the conduct of the clinical research. Grant support: National Institutes of Health (AI-7263I , -72634, -72676, -32535, and -72632). Reprints or correspondence: Dr. Roger Detels, Dept. of Epidemiology, UCLA School of Public Health, 10833 Le Conte Ave., Los Angeles, CA 90024-1772. * Present affiliation: Institute of Public Health, Medical College, National Taiwan University, Taipei, Taiwan, Republic ofChina.

PY - 1993/2

Y1 - 1993/2

N2 - The Multicenter AIDS Cohort Study (MACS) was designed to study the natural history of human immunodeficiency virus type 1 (HIV-1) infection, including the relationship between hepatitis B virus (HBV) and HIV-1 infection. In total, 4954 homosexual men were recruited from April 1984 through March 1985 and have been followed up thereafter every 6 months. Hepatitis B surface antigen and hepatitis B core antibody were tested for at the first visit by RIA or EIA; HIV-1 antibody testing was done at each visit by ELISA and confirmed by Western blot assay. The role of HBV infection in HIV-1 seroconversion was studied by stratification for sexual behavior and disease visit by visit. The adjusted risk ratio was 2.02 for hepatitis Bsurface antigen carriers and 2.14 for hepatitis-immune cases compared with hepatitis B-susceptible subjects. Similar results were obtained using a logistic regression model. After taking into account changes in sexual behavior and disease over time, the authors conclude that past HBV infection remains suspect as a cofactor or as a surrogate for other factors associated with HIV-1 seroconversion.

AB - The Multicenter AIDS Cohort Study (MACS) was designed to study the natural history of human immunodeficiency virus type 1 (HIV-1) infection, including the relationship between hepatitis B virus (HBV) and HIV-1 infection. In total, 4954 homosexual men were recruited from April 1984 through March 1985 and have been followed up thereafter every 6 months. Hepatitis B surface antigen and hepatitis B core antibody were tested for at the first visit by RIA or EIA; HIV-1 antibody testing was done at each visit by ELISA and confirmed by Western blot assay. The role of HBV infection in HIV-1 seroconversion was studied by stratification for sexual behavior and disease visit by visit. The adjusted risk ratio was 2.02 for hepatitis Bsurface antigen carriers and 2.14 for hepatitis-immune cases compared with hepatitis B-susceptible subjects. Similar results were obtained using a logistic regression model. After taking into account changes in sexual behavior and disease over time, the authors conclude that past HBV infection remains suspect as a cofactor or as a surrogate for other factors associated with HIV-1 seroconversion.

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Relationship of Hepatitis B Virus Infection to Human Immunodeficiency Virus Type 1 Infection

Abstract

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