Relationship of dietary monounsaturated fatty acids to blood pressure: The international study of macro/micronutrients and blood pressure

Katsuyuki Miura, Jeremiah Stamler, Ian J. Brown, Hirotsugu Ueshima, Hideaki Nakagawa, Masaru Sakurai, Queenie Chan, Lawrence J. Appel, Akira Okayama, Nagako Okuda, J. David Curb, Beatriz L. Rodriguez, Claire Robertson, Liancheng Zhao, Paul Elliott

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Objective: In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty acid intake of individuals with blood pressure in a cross-sectional study. Methods: The International Study of Macro/Micronutrients and Blood Pressure is a cross-sectional epidemiologic study of 4680 men and women ages 40-59 years from 17 population samples in China, Japan, UK and USA. Nutrient intake data were based on four in-depth multipass 24-h dietary recalls/person and two-timed 24-h urine collections/person. Blood pressure was measured eight times at four visits. Results: Mean monounsaturated fatty acid intake ranged from 8.1%kcal (China) to 12.2%kcal (USA). With sequential models to control for possible confounders (dietary, other), linear regression analyses showed significant inverse relationship of total monounsaturated fatty acid intake with DBP for all participants; for 2238 'nonintervened' individuals, the relationship was stronger. Estimated DBP differences with 2-SD higher monounsaturated fatty acids (5.35%kcal) were-0.82 mmHg (P < 0.05) for all participants and-1.70 mmHg (P < 0.01) for nonintervened individuals. Inverse associations of dietary total oleic acid (main monounsaturated) with blood pressure in nonintervened individuals were not significant, but those of oleic acid from vegetable sources were stronger and significant (P < 0.05). Conclusion: Dietary monounsaturated fatty acid intake, especially oleic acid from vegetable sources, may contribute to prevention and control of adverse blood pressure levels in general populations.

Original languageEnglish (US)
Pages (from-to)1144-1150
Number of pages7
JournalJournal of hypertension
Issue number6
StatePublished - Jun 2013


  • blood pressure
  • monounsaturated fatty acids
  • nutrition
  • oleic acid
  • population study

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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