Relationship between vitamin D status and the vaginal microbiome during pregnancy

Kimberly K. Jefferson; Hardik I. Parikh; Erin M. Garcia; David J. Edwards; Myrna G. Serrano; Martin Hewison; Judith R. Shary; Anna M. Powell; Bruce W. Hollis; Jennifer M. Fettweis; Jerome F. Strauss; Gregory A. Buck; Carol L. Wagner

doi:10.1038/s41372-019-0343-8

Relationship between vitamin D status and the vaginal microbiome during pregnancy

Kimberly K. Jefferson, Hardik I. Parikh, Erin M. Garcia, David J. Edwards, Myrna G. Serrano, Martin Hewison, Judith R. Shary, Anna M. Powell, Bruce W. Hollis, Jennifer M. Fettweis, Jerome F. Strauss, Gregory A. Buck, Carol L. Wagner

School of Medicine

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Objective: Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome. Study design: Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were examined. Result: Gestational age and ethnicity were significantly associated with the microbiome. Megasphaera correlated negatively (p = 0.0187) with 25(OH)D among women of African ancestry. Among controls, women of European ancestry exhibited a positive correlation between plasma 25(OH)D and L. crispatus abundance. Conclusion: Certain vaginal bacteria are associated with plasma 25(OH)D concentration.

Original language	English (US)
Pages (from-to)	824-836
Number of pages	13
Journal	Journal of Perinatology
Volume	39
Issue number	6
DOIs	https://doi.org/10.1038/s41372-019-0343-8
State	Published - Jun 1 2019

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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Jefferson, K. K., Parikh, H. I., Garcia, E. M., Edwards, D. J., Serrano, M. G., Hewison, M., Shary, J. R., Powell, A. M., Hollis, B. W., Fettweis, J. M., Strauss, J. F., Buck, G. A., & Wagner, C. L. (2019). Relationship between vitamin D status and the vaginal microbiome during pregnancy. Journal of Perinatology, 39(6), 824-836. https://doi.org/10.1038/s41372-019-0343-8

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title = "Relationship between vitamin D status and the vaginal microbiome during pregnancy",

abstract = "Objective: Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome. Study design: Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were examined. Result: Gestational age and ethnicity were significantly associated with the microbiome. Megasphaera correlated negatively (p = 0.0187) with 25(OH)D among women of African ancestry. Among controls, women of European ancestry exhibited a positive correlation between plasma 25(OH)D and L. crispatus abundance. Conclusion: Certain vaginal bacteria are associated with plasma 25(OH)D concentration.",

author = "Jefferson, {Kimberly K.} and Parikh, {Hardik I.} and Garcia, {Erin M.} and Edwards, {David J.} and Serrano, {Myrna G.} and Martin Hewison and Shary, {Judith R.} and Powell, {Anna M.} and Hollis, {Bruce W.} and Fettweis, {Jennifer M.} and Strauss, {Jerome F.} and Buck, {Gregory A.} and Wagner, {Carol L.}",

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doi = "10.1038/s41372-019-0343-8",

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AU - Jefferson, Kimberly K.

AU - Parikh, Hardik I.

AU - Garcia, Erin M.

AU - Edwards, David J.

AU - Serrano, Myrna G.

AU - Hewison, Martin

AU - Shary, Judith R.

AU - Powell, Anna M.

AU - Hollis, Bruce W.

AU - Fettweis, Jennifer M.

AU - Strauss, Jerome F.

AU - Buck, Gregory A.

AU - Wagner, Carol L.

PY - 2019/6/1

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N2 - Objective: Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome. Study design: Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were examined. Result: Gestational age and ethnicity were significantly associated with the microbiome. Megasphaera correlated negatively (p = 0.0187) with 25(OH)D among women of African ancestry. Among controls, women of European ancestry exhibited a positive correlation between plasma 25(OH)D and L. crispatus abundance. Conclusion: Certain vaginal bacteria are associated with plasma 25(OH)D concentration.

AB - Objective: Evidence supports an inverse association between vitamin D and bacterial vaginosis (BV) during pregnancy. Furthermore, both the vaginal microbiome and vitamin D status correlate with pregnancy outcome. Women of African ancestry are more likely to experience BV, to be vitamin D deficient, and to have certain pregnancy complications. We investigated the association between vitamin D status and the vaginal microbiome. Study design: Subjects were assigned to a treatment (4400 IU) or a control group (400 IU vitamin D daily), sampled three times during pregnancy, and vaginal 16S rRNA gene taxonomic profiles and plasma 25-hydroxyvitamin D [25(OH)D] concentrations were examined. Result: Gestational age and ethnicity were significantly associated with the microbiome. Megasphaera correlated negatively (p = 0.0187) with 25(OH)D among women of African ancestry. Among controls, women of European ancestry exhibited a positive correlation between plasma 25(OH)D and L. crispatus abundance. Conclusion: Certain vaginal bacteria are associated with plasma 25(OH)D concentration.

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Relationship between vitamin D status and the vaginal microbiome during pregnancy

Abstract

ASJC Scopus subject areas

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