TY - JOUR
T1 - Relationship between sex hormones and cognitive performance in men with substance use
AU - Zilbermint, Mihail F.
AU - Wisniewski, Amy B.
AU - Xu, Xiaoqiang
AU - Selnes, Ola A.
AU - Dobs, Adrian S.
N1 - Funding Information:
This research was supported in part by the Johns Hopkins University and by the National Institute on Drug Abuse, National Institutes of Health (grants: 1R01DA014098-01A2, 5R01DA014098-02, 3R01DA014098-03S1, 5R01DA014098-03, 5R01DA014098-04, 5R01DA014098-05). These organizations had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. ClinicalTrials.gov identifier: NCT00245531 .
PY - 2013
Y1 - 2013
N2 - Background: Hypogonadism is common with opiate-like drug use and may contribute to cognitive abnormalities. With the increasing epidemic of HIV and substance use (SU) worldwide, it is important to understand the impact of these conditions on cognition, which may affect quality of life and possibly decrease adherence to treatment. We hypothesized that men with SU, by virtue of hypogonadism secondary to HIV and/or SU, may demonstrate impaired cognition. Methods: We recruited men aged 18-50 from a population of low income, inner-city individuals. Details of HIV and SU status, serum blood levels of total testosterone (TT), free testosterone (FT) and estradiol (E2) were assessed. All subjects were administered ten neuropsychological tests. Results: Our sample consisted of 68 men (mean age: 43.2 years (SD 5.8), African Americans: 86.6%). The recruited population was primarily from low socioeconomic status and unemployed. The mean level of TT was 553.9. ng/dL (SD 262.0), the mean level of FT was 69.5. pg/mL (SD 34.8), mean E2 was 3.2. pg/mL (SD 4.4). We found that 30.9% were hypogonadal and it was associated with higher SU. We observed some relationships between sex hormones and cognitive domains, however, after adjustment for age, drug use category, education, depression, HIV, there was no statistically significant correlation between cognitive performance and sex hormone levels. Conclusions: In this cross-sectional study of men with a high prevalence of SU and hypogonadism, endogenous levels of TT, FT or E2 were not related to cognitive performance. Other factors need to be identified which may contribute to poor cognitive function in the setting of SU.
AB - Background: Hypogonadism is common with opiate-like drug use and may contribute to cognitive abnormalities. With the increasing epidemic of HIV and substance use (SU) worldwide, it is important to understand the impact of these conditions on cognition, which may affect quality of life and possibly decrease adherence to treatment. We hypothesized that men with SU, by virtue of hypogonadism secondary to HIV and/or SU, may demonstrate impaired cognition. Methods: We recruited men aged 18-50 from a population of low income, inner-city individuals. Details of HIV and SU status, serum blood levels of total testosterone (TT), free testosterone (FT) and estradiol (E2) were assessed. All subjects were administered ten neuropsychological tests. Results: Our sample consisted of 68 men (mean age: 43.2 years (SD 5.8), African Americans: 86.6%). The recruited population was primarily from low socioeconomic status and unemployed. The mean level of TT was 553.9. ng/dL (SD 262.0), the mean level of FT was 69.5. pg/mL (SD 34.8), mean E2 was 3.2. pg/mL (SD 4.4). We found that 30.9% were hypogonadal and it was associated with higher SU. We observed some relationships between sex hormones and cognitive domains, however, after adjustment for age, drug use category, education, depression, HIV, there was no statistically significant correlation between cognitive performance and sex hormone levels. Conclusions: In this cross-sectional study of men with a high prevalence of SU and hypogonadism, endogenous levels of TT, FT or E2 were not related to cognitive performance. Other factors need to be identified which may contribute to poor cognitive function in the setting of SU.
KW - Cognitive function
KW - Estradiol
KW - Illicit drug users
KW - Sex hormones
KW - Substance use
KW - Testosterone
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U2 - 10.1016/j.drugalcdep.2012.08.024
DO - 10.1016/j.drugalcdep.2012.08.024
M3 - Article
C2 - 23021515
AN - SCOPUS:84881005673
SN - 0376-8716
VL - 128
SP - 250
EP - 254
JO - Drug and alcohol dependence
JF - Drug and alcohol dependence
IS - 3
ER -